(3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one

Base Information

Chemical Name:(3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one
CAS No.:917567-08-9
Molecular Formula:C₂₇H₂₈O₅
Molecular Weight:432.516
Hs Code.:

Synonyms:(3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one

Suppliers and Price of (3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one

There total 8 articles about (3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1314972-33-2
(3R,4R,5R)-3,4-bis(benzyloxy)-5-(benzyloxymethyl)-3-methyl-tetrahydro-furan-2-ol

: 917567-08-9
(3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one

Guidance literature:: With acetic anhydride; In dimethyl sulfoxide; at 20 ℃; for 17h;

Reference yield: 89.0%

: 492-30-8,7306-56-1,19774-08-4,36791-96-5,36791-97-6,53008-90-5,53008-96-1,53008-97-2,86204-17-3,86204-18-4,93636-22-7
2-C-methyl-D-ribono-1,4-lactone

: 100-39-0
benzyl bromide

: 917567-08-9
(3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one

Guidance literature:: 2-C-methyl-D-ribono-1,4-lactone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -10 ℃; for 1h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at -10 ℃; for 48.5h; Inert atmosphere;
DOI:10.1002/ejoc.201501219

Reference yield:

: 100-44-7
benzyl chloride

: 917567-08-9
(3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / toluene; water / 1 h / Reflux; Dean-Stark

1.2: 16 h / Reflux; Dean-Stark

2.1: water; sulfuric acid; acetic acid / 8 h / 70 °C

3.1: acetic anhydride / dimethyl sulfoxide / 16 h / 20 °C / Inert atmosphere

With sulfuric acid; water; acetic anhydride; acetic acid; potassium hydroxide; In water; dimethyl sulfoxide; toluene;