2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

• Chemical Name: 2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS No.: 1048674-87-8
• Molecular Formula: C₃₁H₃₄ClN₅O₆S
• Molecular Weight: 640.16

Synonyms:2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property of 2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of 2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 1 articles about 2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid (1048674-91-4) → 2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester (1048674-87-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester (1048674-87-8) + N1-(Pyridin-3-yl)-ethane-1,2-diamine (62491-92-3) → 2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid [2-(pyridin-3-ylamino)-ethyl]-amide (1048675-00-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

N1-(6-Methoxy-pyridin-3-yl)-ethane-1,2-diamine + 2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester (1048674-87-8) → 2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid [2-(6-methoxy-pyridin-3-ylamino)-ethyl]-amide (1048674-99-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid

Downstream raw materials:

2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid [2-(pyridin-3-ylamino)-ethyl]-amide

2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid [2-(6-methoxy-pyridin-3-ylamino)-ethyl]-amide

2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid [2-(4-methoxy-phenylamino)-ethyl]-amide

2'-Chloro-5'-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-biphenyl-3-carboxylic acid [(4-methoxy-phenylcarbamoyl)-methyl]-amide

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