(S)-1-Benzyl-pyrrolidine-2-carboxylic acid bis-((S)-1-benzyl-pyrrolidin-2-ylmethyl)-amide

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Chemical Name:(S)-1-Benzyl-pyrrolidine-2-carboxylic acid bis-((S)-1-benzyl-pyrrolidin-2-ylmethyl)-amide
CAS No.:211805-57-1
Molecular Formula:C₃₆H₄₆N₄O
Molecular Weight:550.787
Hs Code.:

Synonyms:(S)-1-Benzyl-pyrrolidine-2-carboxylic acid bis-((S)-1-benzyl-pyrrolidin-2-ylmethyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-Benzyl-pyrrolidine-2-carboxylic acid bis-((S)-1-benzyl-pyrrolidin-2-ylmethyl)-amide

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Technology Process of (S)-1-Benzyl-pyrrolidine-2-carboxylic acid bis-((S)-1-benzyl-pyrrolidin-2-ylmethyl)-amide

There total 4 articles about (S)-1-Benzyl-pyrrolidine-2-carboxylic acid bis-((S)-1-benzyl-pyrrolidin-2-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 31795-93-4
N-benzyl-L-proline

: 211805-54-8
N,N-bis([(S)-1-benzylpyrrolidin-2-yl]methyl)amine

: 211805-57-1
(S)-1-Benzyl-pyrrolidine-2-carboxylic acid bis-((S)-1-benzyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; 1.) 0 deg C, 2 h, 2.) room temperature, 12 h;
DOI:10.1021/jo9804689

Reference yield:

: 31795-93-4
N-benzyl-L-proline

: 211805-57-1
(S)-1-Benzyl-pyrrolidine-2-carboxylic acid bis-((S)-1-benzyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / EDC, HOBt, Et₃N / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) room temperature, 12 h

2: 90 percent / LiAlH₄ / tetrahydrofuran / 20 h / Heating

3: 94 percent / EDC, HOBt, Et₃N / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) room temperature, 12 h

With lithium aluminium tetrahydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9804689

Reference yield:

: 96948-23-1
1-[(2S)-N-Benzylpyrrolidin-2-yl]methanamine

: 211805-57-1
(S)-1-Benzyl-pyrrolidine-2-carboxylic acid bis-((S)-1-benzyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / EDC, HOBt, Et₃N / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) room temperature, 12 h

2: 90 percent / LiAlH₄ / tetrahydrofuran / 20 h / Heating

3: 94 percent / EDC, HOBt, Et₃N / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) room temperature, 12 h

With lithium aluminium tetrahydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9804689