5-{3-[2-(2,3-dihydroxypropyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

Base Information

Chemical Name:5-{3-[2-(2,3-dihydroxypropyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile
CAS No.:1258853-02-9
Molecular Formula:C₂₄H₂₆N₄O₄
Molecular Weight:434.495
Hs Code.:

Synonyms:5-{3-[2-(2,3-dihydroxypropyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

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Chemical Property of 5-{3-[2-(2,3-dihydroxypropyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

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Technology Process of 5-{3-[2-(2,3-dihydroxypropyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

There total 7 articles about 5-{3-[2-(2,3-dihydroxypropyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1258855-73-0
2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile mono-trifluoroacetate

: 56-82-6,367-47-5,26793-98-6
Glyceraldehyde

: 1258853-02-9
5-{3-[2-(2,3-dihydroxypropyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: 2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile mono-trifluoroacetate; Glyceraldehyde; With acetic acid; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 96h;

With water; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258853-02-9
5-{3-[2-(2,3-dihydroxypropyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: pyridine / toluene / 3 h / 120 °C / Reflux

3.1: dichloromethane / 0 - 20 °C

4.1: acetic acid / dichloromethane; tetrahydrofuran / 0.17 h / 20 °C

4.2: 96 h / 20 °C

With pyridine; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1072948-37-8
3-cyano-4-[(1-methylethyl)oxy]benzoyl chloride

: 1258853-02-9
5-{3-[2-(2,3-dihydroxypropyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / toluene / 3 h / 120 °C / Reflux

2.1: dichloromethane / 0 - 20 °C

3.1: acetic acid / dichloromethane; tetrahydrofuran / 0.17 h / 20 °C

3.2: 96 h / 20 °C

With pyridine; acetic acid; In tetrahydrofuran; dichloromethane; toluene;