4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoate

Base Information

Chemical Name:4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoate
CAS No.:1284215-29-7
Molecular Formula:C₂₅H₂₄FNO₃
Molecular Weight:405.469
Hs Code.:

Synonyms:4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoate

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Chemical Property of 4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoate

Chemical Property:

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Technology Process of 4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoate

There total 6 articles about 4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255928-52-9
4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate

: 1284215-29-7
4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; isopropyl alcohol; Inert atmosphere;
DOI:10.1021/ja104999v

Reference yield:

: 1255928-47-2
3-(dimethylamino)-5-(ethoxycarbonyl)benzoic acid

: 1284215-29-7
4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 4 h / 0 °C / Reflux

2.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

3.1: triethyl phosphite / 3 h / 150 °C

3.2: 18 h / 0 °C

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C

6.1: hydrogenchloride; water / isopropyl alcohol; tetrahydrofuran / 18 h

With hydrogenchloride; dmap; N-chloro-succinimide; borane-THF; water; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 1255928-48-3
ethyl 3-(dimethylamino)-5-(hydroxymethyl)benzoate

: 1284215-29-7
4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

2.1: triethyl phosphite / 3 h / 150 °C

2.2: 18 h / 0 °C

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C

5.1: hydrogenchloride; water / isopropyl alcohol; tetrahydrofuran / 18 h

With hydrogenchloride; dmap; N-chloro-succinimide; water; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;