4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate

Base Information

Chemical Name:4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate
CAS No.:1255928-52-9
Molecular Formula:C₂₇H₂₈FNO₄
Molecular Weight:449.522
Hs Code.:

Synonyms:4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate

Suppliers and Price of 4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate

There total 5 articles about 4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371-41-5
4-Fluorophenol

: 1255928-51-8
(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoic acid

: 1255928-52-9
4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja104999v

Reference yield:

: 1255928-47-2
3-(dimethylamino)-5-(ethoxycarbonyl)benzoic acid

: 1255928-52-9
4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 4 h / 0 °C / Reflux

2.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

3.1: triethyl phosphite / 3 h / 150 °C

3.2: 18 h / 0 °C

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C

With dmap; N-chloro-succinimide; borane-THF; water; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1255928-48-3
ethyl 3-(dimethylamino)-5-(hydroxymethyl)benzoate

: 1255928-52-9
4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

2.1: triethyl phosphite / 3 h / 150 °C

2.2: 18 h / 0 °C

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C

With dmap; N-chloro-succinimide; water; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane;