N-{3-cyano-3-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

Base Information

Chemical Name:N-{3-cyano-3-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide
CAS No.:1202410-59-0
Molecular Formula:C₂₆H₃₀FN₅O₂
Molecular Weight:463.555
Hs Code.:

Synonyms:N-{3-cyano-3-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

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Chemical Property of N-{3-cyano-3-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

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Technology Process of N-{3-cyano-3-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

There total 10 articles about N-{3-cyano-3-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 582325-22-2
6-(3-fluorophenyl)-3-pyridinecarboxylic acid

: 1202411-83-3
3-amino-1-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexanecarbonitrile

: 1202410-59-0
N-{3-cyano-3-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 17h;

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 1202410-59-0
N-{3-cyano-3-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 20 h / Reflux

1.2: pH 3

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 0 - 20 °C

With tetrabutylammomium bromide; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1202411-77-5
N,N-dibenzyl-1,5-dichloropentan-2-amine

: 1202410-59-0
N-{3-cyano-3-[(4-ethylpiperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 79 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 16 h / 52 °C

2.2: pH 6

3.1: HATU / N,N-dimethyl-formamide / 136.83 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C / 760.05 Torr

5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 0 - 20 °C

With lithium hydroxide monohydrate; water; hydrogen; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;