4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol

Base Information

Chemical Name:4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol
CAS No.:1422250-84-7
Molecular Formula:C₂₁H₂₀O₃
Molecular Weight:320.388
Hs Code.:

Synonyms:4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol

Suppliers and Price of 4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol

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Technology Process of 4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol

There total 4 articles about 4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1422250-64-3
7-bromo-2-(4-methoxyphenyl)-5-methylbenzo[b]furan

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1422250-84-7
4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 60 ℃; for 2h;
DOI:10.1016/j.tet.2012.12.058

Reference yield:

: 180639-95-6
2-bromo-6-iodo-4-methylphenol

: 1422250-84-7
4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; copper(l) iodide; L-proline / toluene / 8 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; caesium carbonate / 1,4-dioxane / 2 h / 60 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; caesium carbonate; L-proline; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; toluene;
DOI:10.1016/j.tet.2012.12.058

Reference yield:

: 106-44-5
p-cresol

: 1422250-84-7
4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride; N-Bromosuccinimide / dichloromethane / 20 °C

2: iodine; silver sulfate / ethanol / 20 °C

3: potassium phosphate; copper(l) iodide; L-proline / toluene / 8 h / 20 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; caesium carbonate / 1,4-dioxane / 2 h / 60 °C

With aluminum (III) chloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; copper(l) iodide; iodine; caesium carbonate; silver sulfate; L-proline; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2012.12.058