180639-95-6

Upstream product

• 6627-55-0 2-bromo-p-cresol 
• 106-44-5 p-cresol 

Downstream Products

• 4789-95-1 3-Bromo-4-hydroxy-5-iodo-benzaldehyde 
• 87682-04-0 3,3'-Dibromo-5,5'-dimethyl<1,1'-biphenyl>-2,2'-diol 
• 1335094-32-0 1-(5-methyl-2-phenylbenzo[b]furan-7-yl)piperidine 
• 1335094-33-1 1-(5-methyl-2-phenylbenzo[b]furan-7-yl)piperazine 
• 1335094-13-7 2-phenyl-5-methyl-7-bromobenzo[b]furan 
• 1422250-82-5 7-((4-methoxyphenyl)ethynyl)-5-methyl-2-phenylbenzo[b]furan 
• 1422250-84-7 4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)-2-methylbut-3-yn-2-ol 
• 1422250-86-9 2-methyl-4-(5-methyl-2-phenylbenzo[b]furan-7-yl)but-3-yn-2-ol 
• 1422250-92-7 (E)-5-fluoro-2-phenyl-7-styrylbenzo[b]furan 
• 1422251-03-3 4-(2-(4-methoxyphenyl)-5-methylbenzo[b]furan-7-yl)morpholine 
• 1422250-64-3 7-bromo-2-(4-methoxyphenyl)-5-methylbenzo[b]furan 

Relevant academic research and scientific papers

Enhancing the synthetic utility of 3-haloaryne intermediates by their efficient Generation from readily synthesizable ortho-iodoaryl triflate-type precursors

Generation of 3-haloarynes from o-iodoaryl triflate-type precursors is reported. The method enables the generation of 3-fluorobenzyne with significantly high electrophilicity at -78 °C, allowing the formation of a three-component-coupled product between 3

Multisubstituted benzo[b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process

Full details as well as the study of the scope, limitations, and further elaboration of a straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[b]furans from 2-bromo- and 2-chloro-6-iodo-4- substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process is described. Functionalization at the C(7) position is carried out by Suzuki-Miyaura cross-coupling, alkynylation, alkenylation, and C-N bond forming reactions. A one-pot protocol for the synthesis of 2,5,7-trisubstituted benzo[b]furans is also reported.

2,5,7-Trisubstituted benzo[b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process

A straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[b]furans from 2-bromo- and 2-chloro-6-iodo-4-substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process is described. Functionalization at the C(7) position is carried out by Suzuki-Miyaura cross-coupling and C-N bond forming reactions.

INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES

Compounds of Formula (I) or Formula (II) or pharmaceutically acceptable salts thereof, wherein m, n, p, Ar R1 R2, R4 R5 and R6 are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using these compounds in the treatment of Alzheimer's disease or as cognitive enhancer.