63777-70-8

Basic information

• Product Name: Benzene, 1-(azidomethyl)-2-chloro-
• CAS NO: 63777-70-8
• Molecular Formula: C7H6ClN3
• Molecular Weight: 167.598
• Mol File: 63777-70-8.mol
• Article Data: 67

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(azidomethyl)-2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(azidomethyl)-2-chloro-(63777-70-8)
• EPA Substance Registry System: Benzene, 1-(azidomethyl)-2-chloro-(63777-70-8)

Safety Data

• Hazardous Substances Data: 63777-70-8(Hazardous Substances Data)

Upstream product

• 17849-38-6 2-Chlorobenzyl alcohol 
• 109131-75-1 2-chloro-1-(4-methylbenzenesulfonyloxymethyl)benzene 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 5651-83-2 3-methoxy-4-(prop-2-ynyloxy)benzaldehyde 
• 118-91-2 ortho-chlorobenzoic acid 
• 108-90-7 chlorobenzene 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 

Downstream Products

• 141072-02-8 di-tert-butyl 1-(2-chlorobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 93444-91-8 5-amino-1-(2-chlorobenzyl)-1H-1,2,3-triazole-4-carboxamide 
• 1253801-28-3 4-amino-N-((1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide 
• 1370251-38-9 N-((1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine 
• 141072-15-3 methyl 1-(2-chlorobenzyl)-1H-1,2,3-triazole-4-carboxylate 

Relevant articles and documents

Synthesis, inhibition properties against xanthine oxidase and molecular docking studies of dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives

This study focused on synthesis various dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives under the conditions of green chemistry without the use of solvent and catalysts. Their inhibition properties were also investigated on xanthine oxidase (XO) activity. All dimethanol and dicarboxylate derivatives exhibited significant inhibition activities with IC50 values ranging from 0.71 to 2.25 μM. Especially, (1-(3-bromobenzyl)-1H-1,2,3-triazole-4,5-diyl)dimethanol (5c) and dimethyl 1-(4-chlorobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate (6 g) compounds were found to be the most promising derivatives on the XO enzyme inhibition with IC50 values 0.71 and 0.73 μM, respectively. Moreover, the double docking procedure was to evaluate compound modes of inhibition and their interactions with the protein (XO) at atomic level. Surprisingly, the docking results showed a good correlation with IC50 [correlation coefficient (R2 = 0.7455)]. Also, the docking results exhibited that the 5c, 6f and 6 g have lowest docking scores ?4.790, ?4.755, and ?4.730, respectively. These data were in agreement with the IC50 values. These results give promising beginning stages to assist in the improvement of novel and powerful inhibitor against XO.

NOVEL DIBENZOOXAPHOSPHININE OXIDE DERIVATIVE COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEGENERATIVE DISEASE COMPRISING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to a novel dibenzooxininin oxide derivative compound having various nitrogen-containing substituents introduced at 6-position of a dibenzooxaphosphorin oxide mononuclear, and to the use thereof. The present invention relates to a pharmaceutical composition for preventing or treating degenerative diseases and a health supplement food composition for preventing or treating degenerative diseases, comprising the dibenzooxaphosphorin oxide derivative compound of the present invention.

Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies

The current study was aimed to discover potent inhibitors of α-glucosidase enzyme. A 25 membered library of new 1,2,3-triazole derivatives of hydrochlorothiazide (1) (HCTZ, a diuretic drug also being used for the treatment of high blood pressure) was synt