(S)-1-((1R,2R,3S,4S,6R)-6-Benzyloxy-3-benzyloxymethyl-4-methoxymethoxy-1-methyl-bicyclo[2.2.2]oct-2-yl)-ethane-1,2-diol

Base Information

Chemical Name:(S)-1-((1R,2R,3S,4S,6R)-6-Benzyloxy-3-benzyloxymethyl-4-methoxymethoxy-1-methyl-bicyclo[2.2.2]oct-2-yl)-ethane-1,2-diol
CAS No.:155192-16-8
Molecular Formula:C₂₈H₃₈O₆
Molecular Weight:470.606
Hs Code.:

Synonyms:(S)-1-((1R,2R,3S,4S,6R)-6-Benzyloxy-3-benzyloxymethyl-4-methoxymethoxy-1-methyl-bicyclo[2.2.2]oct-2-yl)-ethane-1,2-diol

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Chemical Property of (S)-1-((1R,2R,3S,4S,6R)-6-Benzyloxy-3-benzyloxymethyl-4-methoxymethoxy-1-methyl-bicyclo[2.2.2]oct-2-yl)-ethane-1,2-diol

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Technology Process of (S)-1-((1R,2R,3S,4S,6R)-6-Benzyloxy-3-benzyloxymethyl-4-methoxymethoxy-1-methyl-bicyclo[2.2.2]oct-2-yl)-ethane-1,2-diol

There total 5 articles about (S)-1-((1R,2R,3S,4S,6R)-6-Benzyloxy-3-benzyloxymethyl-4-methoxymethoxy-1-methyl-bicyclo[2.2.2]oct-2-yl)-ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 155192-04-4
(1S, 2S, 3R, 4R, 5R, 4'S)-5-benzyloxy-2-benzyloxymethyl-1-methoxymethyloxy-4-methyl-3-(2',2'-dimethyl-1',3'-dioxolan-4'yl)bicyclo<2.2.2>octane

: 155192-16-8
(S)-1-((1R,2R,3S,4S,6R)-6-Benzyloxy-3-benzyloxymethyl-4-methoxymethoxy-1-methyl-bicyclo[2.2.2]oct-2-yl)-ethane-1,2-diol

Guidance literature:: With acetic acid; at 25 ℃; for 24h;
DOI:10.1016/S0040-4020(01)80785-7

Reference yield:

: 81703-93-7
methyl (2E)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate

: 155192-16-8
(S)-1-((1R,2R,3S,4S,6R)-6-Benzyloxy-3-benzyloxymethyl-4-methoxymethoxy-1-methyl-bicyclo[2.2.2]oct-2-yl)-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, 2.) lithium aluminum hydride / 1.) THF, -78 deg C to 0 deg C, 17 h, 2.) THF, 0 deg C to 22 deg C, 14 h

2: 89 percent / 50percent sodium hydride in oil / dimethylformamide / 7 h / 0 - 22 °C

3: 83 percent / 80percent acetic acid / 24 h / 25 °C

With lithium aluminium tetrahydride; sodium hydride; acetic acid; lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80785-7

Reference yield:

: 100-39-0
benzyl bromide

: 155192-16-8
(S)-1-((1R,2R,3S,4S,6R)-6-Benzyloxy-3-benzyloxymethyl-4-methoxymethoxy-1-methyl-bicyclo[2.2.2]oct-2-yl)-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 50percent sodium hydride in oil / dimethylformamide / 7 h / 0 - 22 °C

2: 83 percent / 80percent acetic acid / 24 h / 25 °C

With sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80785-7