2-(4-bromophenylthio)-2-phenylacetyl chloride

Base Information

• Chemical Name: 2-(4-bromophenylthio)-2-phenylacetyl chloride
• CAS No.: 1262226-96-9
• Molecular Formula: C₁₄H₁₀BrClOS
• Molecular Weight: 341.656
• Mol file: 1262226-96-9.mol

Synonyms:2-(4-bromophenylthio)-2-phenylacetyl chloride

Chemical Property of 2-(4-bromophenylthio)-2-phenylacetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-bromophenylthio)-2-phenylacetyl chloride

There total 5 articles about 2-(4-bromophenylthio)-2-phenylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((4-bromophenyl)thio)-N-(2-hydroxyphenyl)-2-phenylacetamide → 2-(4-bromophenylthio)-2-phenylacetyl chloride (1262226-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 16 h / 100 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.9b02424

Reference yield:

para-bromobenzenethiol (106-53-6) → 2-(4-bromophenylthio)-2-phenylacetyl chloride (1262226-96-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium phosphate; copper(l) iodide / dimethyl sulfoxide / 10 h / 90 °C / Inert atmosphere

2: zinc(II) chloride; hydrogenchloride / ethanol; water / 16 h / 100 °C

3: sodium hydroxide / ethanol / 16 h / 100 °C

4: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; copper(l) iodide; oxalyl dichloride; sodium hydroxide; zinc(II) chloride; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.9b02424

Reference yield:

2-benzyl-1,3-benzoxazole (2008-07-3) → 2-(4-bromophenylthio)-2-phenylacetyl chloride (1262226-96-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium phosphate; copper(l) iodide / dimethyl sulfoxide / 10 h / 90 °C / Inert atmosphere

2: zinc(II) chloride; hydrogenchloride / ethanol; water / 16 h / 100 °C

3: sodium hydroxide / ethanol / 16 h / 100 °C

4: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; copper(l) iodide; oxalyl dichloride; sodium hydroxide; zinc(II) chloride; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.9b02424

upstream raw materials:

2-benzyl-1,3-benzoxazole

para-bromobenzenethiol

Downstream raw materials:

2-((4-bromophenyl)thio)-N-(5-bromopyridin-2-yl)-2-phenylacetamide