<<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane

Base Information

• Chemical Name: <<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane
• CAS No.: 139219-30-0
• Molecular Formula: C₂₈H₃₃BrO₅Si
• Molecular Weight: 557.557
• Mol file: 139219-30-0.mol

Synonyms:<<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane

Chemical Property of <<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane

There total 1 articles about <<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-5,6,8-trimethoxy-3-(phenylethynyl)-4-<(triethylsilyl)oxy>-1-naphthalenol + dimethyl sulfate (77-78-1) → <<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane (139219-30-0)

Guidance literature:

With sodium hydroxide; sodium dithionite; tetrabutylammomium bromide; Yield given. Multistep reaction; 1) H₂O, CH₂Cl₂, 30 min, RT, 2) H₂O, CH₂Cl₂, overnight;

DOI:10.1016/S0040-4020(01)88016-9

Reference yield: 96.0%

<<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane (139219-30-0) → 3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenol (139219-31-1)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; for 0.5h;

DOI:10.1016/S0040-4020(01)88016-9

Reference yield:

<<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane (139219-30-0) → <3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-6H-cyclopentisoquinolin-8-yl><1,4,5,6,8-pentamethoxy-3-(phenylethynyl)-2-naphthalenyl>methanone (145222-92-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Bu₄NF

2: NaOH

3: 1.) BuLi / 1.) THF, Et₂O, hexane, -78 deg C, 5 min, 2.) THF, Et₂O, hexane, 60 min

4: 80 percent / Ph₃BiCO₃, pyridine / toluene / 48 h / 80 °C

With pyridine; sodium hydroxide; n-butyllithium; Ph₃BiCO₃; tetrabutyl ammonium fluoride; In toluene;

DOI:10.1021/ja00104a009

upstream raw materials:

dimethyl sulfate

Downstream raw materials:

3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenol

2-bromo-1,4,5,6,8-pentamethoxy-3-(phenylethynyl)naphthalene

3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxyspiro<2H-benzindene-2,8'-<8H>cyclopentisoquinoline>-1,3-dione

3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxy-3-(phenylmethylene)spiro<2H-benzindene-2,8'-<8H>cyclopentisoquinolin>-1(3H)-one