145222-92-0Relevant articles and documents
Total synthesis of crystalline (±)-fredericamycin A. Use of radical spirocyclization
Clive, Derrick L. J.,Tao, Yong,Khodabocus, Ahmad,Wu, Yong-Jin,Angoh, A. Ga?tan,Bennett, Sharon M.,Boddy, Christopher N.,Bordeleau, Luc,Kellner, Dont,Kleiner, Galit,Middleton, Donald S.,Nichols, Christopher J.,Richardson, Scott R.,Vernon, Peter G.
, p. 11275 - 11286 (2007/10/02)
Crystalline (±)-fredericamycin A (1) was synthesized using, as a key step, 5-exo-digonal radical closure of selenide 55. The selenide was generated from the corresponding ketone 54, itself assembled from two components: aldehyde 29 and bromonaphthalene 48
Total Synthesis of (+/-)-Fredericamycin A. Use of Radical Spirocyclization
Clive, Derrick L. J.,Tao, Yong,Khodabocus, Ahmad,Wu, Yong-Jin,Angoh, A. Gaoetan,et al.
, p. 1489 - 1490 (2007/10/02)
(+/-)-Fredericamycin A 1 is synthesized using 5-exo-digonal radical closure of selenide 15 (Scheme 2), and an unusual procedure for both selective demethylation of the advanced intermediate 22 and adjustment of the stereochemistry in the pentadienyl side