5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N⁶-ethyladenosine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N⁶-ethyladenosine
CAS No.:588698-76-4
Molecular Formula:C₃₉H₄₉N₅O₆Si
Molecular Weight:711.933
Hs Code.:

5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N<sup>6</sup>-ethyladenosine

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N⁶-ethyladenosine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N⁶-ethyladenosine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N⁶-ethyladenosine

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N⁶-ethyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 588698-72-0
5'-O-(4,4'-dimethoxytrityl)-N⁶-ethyladenosine

: 588698-76-4
5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N⁶-ethyladenosine

Guidance literature:: With silver nitrate; triethylamine; In tetrahydrofuran; at 20 ℃; for 8h;
DOI:10.1021/ja029742d

Reference yield:

: 74465-47-7
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-bromo-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

: 588698-76-4
5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N⁶-ethyladenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / methanol / 8 h / 20 °C

2: 60 percent / pyridine; AgNO₃ / tetrahydrofuran / 20 °C

3: 65 percent / Et₃N; AgNO₃ / tetrahydrofuran / 8 h / 20 °C

With pyridine; silver nitrate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/ja029742d

Reference yield:

: 14357-08-5
N-ethyladenosine

: 588698-76-4
5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N⁶-ethyladenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / pyridine; AgNO₃ / tetrahydrofuran / 20 °C

2: 65 percent / Et₃N; AgNO₃ / tetrahydrofuran / 8 h / 20 °C

With pyridine; silver nitrate; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja029742d