[3'-(benzylcarbamoyl-methyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester

Base Information

• Chemical Name: [3'-(benzylcarbamoyl-methyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester
• CAS No.: 1026643-13-9
• Molecular Formula: C₂₄H₂₃NO₅S
• Molecular Weight: 437.516

Synonyms:[3'-(benzylcarbamoyl-methyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester

Chemical Property of [3'-(benzylcarbamoyl-methyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester

Chemical Property:

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Technology Process of [3'-(benzylcarbamoyl-methyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester

There total 5 articles about [3'-(benzylcarbamoyl-methyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzylamine (100-46-9) + (3'-chlorocarbonylmethyl-biphenyl-4-sulfonyl)-acetic acid methyl ester → [3'-(benzylcarbamoyl-methyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester (1026643-13-9)

Guidance literature:

benzylamine; (3'-chlorocarbonylmethyl-biphenyl-4-sulfonyl)-acetic acid methyl ester; With PS-DIEA; In dichloromethane; at 20 ℃;

With PS-isocyanate; N-ethyl-N,N-diisopropylamine; at 20 ℃;

DOI:10.1021/jm034206x

Reference yield:

3-iodophenylacetic acid (1878-69-9) → [3'-(benzylcarbamoyl-methyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester (1026643-13-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: MgSO₄; H₂SO₄ / CH₂Cl₂ / 20 °C

2.1: 58 percent / Ph₃As; Pd₂(dba)3*CHCl₃; CuI / dimethylformamide / 4 h / 75 °C

3.1: TFA / CH₂Cl₂ / 6 h / 20 °C

4.1: (COCl)2; DMF / CH₂Cl₂ / 2 h / 20 °C

5.1: PS-DIEA / CH₂Cl₂ / 20 °C

5.2: PS-isocyanate; DIPEA / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; oxalyl dichloride; PS-DIEA; triphenyl-arsane; sulfuric acid; magnesium sulfate; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 2.1: Stille cross-coupling;

DOI:10.1021/jm034206x

Reference yield:

2-(3-iodophenyl)acetic acid t-butyl ester → [3'-(benzylcarbamoyl-methyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester (1026643-13-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 58 percent / Ph₃As; Pd₂(dba)3*CHCl₃; CuI / dimethylformamide / 4 h / 75 °C

2.1: TFA / CH₂Cl₂ / 6 h / 20 °C

3.1: (COCl)2; DMF / CH₂Cl₂ / 2 h / 20 °C

4.1: PS-DIEA / CH₂Cl₂ / 20 °C

4.2: PS-isocyanate; DIPEA / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; oxalyl dichloride; PS-DIEA; triphenyl-arsane; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1.1: Stille cross-coupling;

DOI:10.1021/jm034206x

upstream raw materials:

benzylamine

3-iodophenylacetic acid

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