6-chloro-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione

Base Information

• Chemical Name: 6-chloro-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione
• CAS No.: 19918-37-7
• Molecular Formula: C6H4 Cl N3 S
• Molecular Weight: 185.637
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60366593
• Wikidata: Q82151873
• Mol file: 19918-37-7.mol

Synonyms:19918-37-7;6-chloro-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione;6-chloro-3H-imidazo[4,5-b]pyridine-2-thiol;6-chloro-1H-imidazo[4,5-b]pyridine-2(3H)-thione;6-chloro-1,3-dihydroimidazo[4,5-b]pyridine-2-thione;DTXSID60366593;LT0067;AKOS000268589;AKOS005169786;CCG-320986;CS-0221343;EU-0048993;EN300-08920;F77017;Z55928993

Chemical Property of 6-chloro-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione

Chemical Property:

• Vapor Pressure: 0.00032mmHg at 25°C
• Boiling Point: 320.3°Cat760mmHg
• Flash Point: 147.5°C
• PSA: 80.37000
• Density: 1.65g/cm³
• LogP: 1.90000
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 184.9814460
• Heavy Atom Count: 11
• Complexity: 187

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-1H-imidazo[4,5-b]pyridine-2(3H)-thione 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC2=C1NC(=S)N2)Cl

Technology Process of 6-chloro-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione

There total 6 articles about 6-chloro-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

carbon disulfide (75-15-0,12122-00-8) + 5-chloro-2,3-diaminopyridine (25710-20-7) → 6-chloro-1H-imidazo[4,5-b]pyridine-2(3H)-thione (19918-37-7)

Guidance literature:

In pyridine; for 5h; Heating;

DOI:10.1007/BF00475602

Reference yield: 98.0%

6-chloro-3H-imidazo-[4,5-b]pyridine (21422-66-2) → 6-chloro-1H-imidazo[4,5-b]pyridine-2(3H)-thione (19918-37-7)

Guidance literature:

With sulfur; at 255 - 260 ℃; for 1h;

DOI:10.1007/BF00475602

Reference yield: 37.0%

5-chloro-2,3-diaminopyridine (25710-20-7) + potassium ethyl xanthogenate (140-89-6) → 6-chloro-1H-imidazo[4,5-b]pyridine-2(3H)-thione (19918-37-7)

Guidance literature:

In ethanol; water; at 80 ℃; Reflux;

DOI:10.1021/jm501434y

upstream raw materials:

carbon disulfide

5-chloro-2,3-diaminopyridine

6-chloro-3H-imidazo-[4,5-b]pyridine

2-amino-5-chloro-3-nitropyridine