3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine

Base Information

Chemical Name:3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine
CAS No.:1404559-22-3
Molecular Formula:C₂₇H₃₈N₆O₃S
Molecular Weight:526.703
Hs Code.:

Synonyms:3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine

Suppliers and Price of 3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Chemenu
tert-Butyl(2S,4R)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate 95%+
1g
$ 1451.00

Chemenu
tert-Butyl(2S,4R)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate 95%+
250mg
$ 786.00

Chemenu
tert-Butyl(2S,4R)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate 95%+
100mg
$ 471.00

Total 5 raw suppliers

Chemical Property of 3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine

Chemical Property:

Boiling Point:706.5±60.0 °C(Predicted)
Density:1.31±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl(2S,4R)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate 95%+ ^*data from reagent suppliers

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Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of 3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine

There total 3 articles about 3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 401564-34-9
3-((2S,4S)-1-tert-butoxycarbonyl-4-hydroxy-2-pyrrolidinylcarbonyl)-1,3-thiazolidine

: 401566-79-8
1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine

: 1404559-22-3
3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine

Guidance literature:: 3-((2S,4S)-1-tert-butoxycarbonyl-4-hydroxy-2-pyrrolidinylcarbonyl)-1,3-thiazolidine; With 2,6-dimethylpyridine; trifluoromethanesulfonic acid anhydride; In dichloromethane; for 0.5h; Cooling with ice;

1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 21h;
DOI:10.1016/j.bmc.2012.08.012

Reference yield:

: 1-tert-butoxycarbonyl-4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine

: 1404559-22-3
3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

2.1: 2,6-dimethylpyridine; trifluoromethanesulfonic acid anhydride / dichloromethane / 0.5 h / Cooling with ice

2.2: 21 h / 20 °C

With 2,6-dimethylpyridine; trifluoromethanesulfonic acid anhydride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2012.08.012

Reference yield:

: 401566-77-6
tert-butyl 4-(3-oxobutanoyl)piperazine-1-carboxylate

: 1404559-22-3
3-{(2S,4R)-1-(tert-butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanesulfonic acid / ethanol / 14 h / 20 °C

1.2: 20 h / 20 °C / pH 3

2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3.1: 2,6-dimethylpyridine; trifluoromethanesulfonic acid anhydride / dichloromethane / 0.5 h / Cooling with ice

3.2: 21 h / 20 °C

With 2,6-dimethylpyridine; methanesulfonic acid; trifluoromethanesulfonic acid anhydride; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.08.012