2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride

Base Information

Chemical Name:2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride
CAS No.:1415999-82-4
Molecular Formula:C₂₇H₂₂F₃N₇O*ClH
Molecular Weight:553.974
Hs Code.:

Synonyms:2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride

Suppliers and Price of 2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride

There total 10 articles about 2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

: 1416000-79-7
tert-butyl 4-(4-(2-(6-aminopyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

: 1415999-82-4
2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride

Guidance literature:: In dichloromethane;

Reference yield:

: 4487-59-6
2-bromo-5-nitropyridine

: 1415999-82-4
2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: iron; hydrogenchloride / ethanol; water / 5 h / Reflux

2: ethanol / 5 h / Reflux

3: diphenylether / 0.75 h / Reflux

4: dimethyl amine; trichlorophosphate / 3 h / Reflux

5: potassium carbonate / tert-butyl alcohol; dichloromethane / 24 h / 20 °C

6: sodium tetrahydroborate; ethanol / 18 h / 20 °C

7: manganese(IV) oxide / dichloromethane / 3 h / 20 °C

8: potassium carbonate / tert-butyl alcohol / 36 h / 160 °C / Sealed tube

9: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 4 h / Inert atmosphere; Reflux

10: hydrogenchloride / dichloromethane / 0.5 h

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; iron; sodium carbonate; potassium carbonate; dimethyl amine; trichlorophosphate; In diphenylether; ethanol; dichloromethane; water; toluene; tert-butyl alcohol;

Reference yield:

: 127094-57-9
4,6-dichloro-(1,5)-naphthyridine-3-carboxylic acid ethyl ester

: 1415999-82-4
2-(6-aminopyridin-3-yl)-10-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / tert-butyl alcohol; dichloromethane / 24 h / 20 °C

2: sodium tetrahydroborate; ethanol / 18 h / 20 °C

3: manganese(IV) oxide / dichloromethane / 3 h / 20 °C

4: N,N-dimethyl acetamide / 0.67 h / 160 °C / Microwave irradiation

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 4 h / Inert atmosphere; Reflux

6: hydrogenchloride / dichloromethane / 0.5 h

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; sodium carbonate; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl acetamide; toluene; tert-butyl alcohol;