N^α-α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Base Information

• Chemical Name: N^α-α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine
• CAS No.: 122903-67-7
• Molecular Formula: C₄₃H₇₆N₆O₁₂Si₂
• Molecular Weight: 925.28

Synonyms:N^α-α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Chemical Property of N^α-α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Chemical Property:

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Technology Process of N^α-α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

There total 5 articles about N^α-α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Boc-Lys(Z)-OSu (34404-36-9) + Nα-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt (122903-77-9) → Nα-α-α-(tert-butyloxycarbonyl)-Nε-(benzyloxycarbonyl)-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine (122903-67-7)

Guidance literature:

With Etifelmin; In N,N-dimethyl-formamide; for 20h; Ambient temperature;

DOI:10.1021/jo00284a031

Reference yield: 71.0%

Nα-α-(tert-butyloxycarbonyl)-Nε-(benzyloxycarbonyl)-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine N-hydroxysuccinimide ester (122903-66-6) + Nε-<<2-(Trimethylsilyl)ethoxy>carbonyl>-L-lysine (85167-75-5) → Nα-α-α-(tert-butyloxycarbonyl)-Nε-(benzyloxycarbonyl)-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine (122903-67-7)

Guidance literature:

With Etifelmin; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 192h;

DOI:10.1021/jo00284a031

Reference yield:

Boc-Lys(Z)-OH (2389-45-9) → Nα-α-α-(tert-butyloxycarbonyl)-Nε-(benzyloxycarbonyl)-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine (122903-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / DCC / 1.) EtOAc, 25 deg C, 3 h, 2.) Et₂O, overnight

2: 86 percent / EDPA / dimethylformamide / 20 h / Ambient temperature

With Etifelmin; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00284a031

upstream raw materials:

Boc-Lys(Z)-OSu

N^α-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt

N^α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine N-hydroxysuccinimide ester

N^ε-<<2-(Trimethylsilyl)ethoxy>carbonyl>-L-lysine

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