(1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-(3,4-dimethoxyphenyl)]methyl ether

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Chemical Name:(1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-(3,4-dimethoxyphenyl)]methyl ether
CAS No.:157982-26-8
Molecular Formula:C₁₈H₂₆O₆S₂
Molecular Weight:402.533
Hs Code.:

Synonyms:(1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-(3,4-dimethoxyphenyl)]methyl ether

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Chemical Property of (1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-(3,4-dimethoxyphenyl)]methyl ether

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Technology Process of (1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-(3,4-dimethoxyphenyl)]methyl ether

There total 3 articles about (1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-(3,4-dimethoxyphenyl)]methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 157982-23-5
(1R,3R)-1,3-dithiane-1,3-dioxide-2-[(1R)-1-(3,4-dimethoxyphenyl)]methanol

: 157982-26-8
(1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-(3,4-dimethoxyphenyl)]methyl ether

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1039/c39940001653

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 157982-26-8
(1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-(3,4-dimethoxyphenyl)]methyl ether

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHMDS / pyridine; tetrahydrofuran / 0.5 h / 0 °C

1.2: 76 percent / pyridine; tetrahydrofuran / 2 h / 0 °C

2.1: 93 percent / PTSA / CH₂Cl₂ / 2 h / 0 - 20 °C

With sodium hexamethyldisilazane; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; dichloromethane; 1.1: Metallation / 1.2: Addition / 2.1: Etherification;
DOI:10.1016/S0040-4020(97)01010-7

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 157982-26-8
(1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-(3,4-dimethoxyphenyl)]methyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / NaHMDS, pyridine / tetrahydrofuran

2: 93 percent / TsOH / CH₂Cl₂

With pyridine; sodium hexamethyldisilazane; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c39940001653