(1R)-S-ethyl [1-(3,4-dimethoxyphenyl)-1-tetrahydropyran-(2RS)-2-yloxy]-thioacetate

Base Information

Chemical Name:(1R)-S-ethyl [1-(3,4-dimethoxyphenyl)-1-tetrahydropyran-(2RS)-2-yloxy]-thioacetate
CAS No.:157982-29-1
Molecular Formula:C₁₇H₂₄O₅S
Molecular Weight:340.441
Hs Code.:

Synonyms:(1R)-S-ethyl [1-(3,4-dimethoxyphenyl)-1-tetrahydropyran-(2RS)-2-yloxy]-thioacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-S-ethyl [1-(3,4-dimethoxyphenyl)-1-tetrahydropyran-(2RS)-2-yloxy]-thioacetate

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Technology Process of (1R)-S-ethyl [1-(3,4-dimethoxyphenyl)-1-tetrahydropyran-(2RS)-2-yloxy]-thioacetate

There total 4 articles about (1R)-S-ethyl [1-(3,4-dimethoxyphenyl)-1-tetrahydropyran-(2RS)-2-yloxy]-thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 199989-10-1
C₃₆H₅₀O₁₁S₄

: 75-08-1
ethanethiol

: 157982-29-1
(1R)-S-ethyl [1-(3,4-dimethoxyphenyl)-1-tetrahydropyran-(2RS)-2-yloxy]-thioacetate

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 2h;
DOI:10.1016/S0040-4020(97)01010-7

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 157982-29-1
(1R)-S-ethyl [1-(3,4-dimethoxyphenyl)-1-tetrahydropyran-(2RS)-2-yloxy]-thioacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / NaHMDS, pyridine / tetrahydrofuran

2: 93 percent / TsOH / CH₂Cl₂

3: 1.) trifluoroacetic anhydride, pyridine, 2.) aq. LiOH / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) THF, from 0 deg C to RT

With pyridine; lithium hydroxide; sodium hexamethyldisilazane; toluene-4-sulfonic acid; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c39940001653

Reference yield:

: 157982-23-5
(1R,3R)-1,3-dithiane-1,3-dioxide-2-[(1R)-1-(3,4-dimethoxyphenyl)]methanol

: 157982-29-1
(1R)-S-ethyl [1-(3,4-dimethoxyphenyl)-1-tetrahydropyran-(2RS)-2-yloxy]-thioacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / TsOH / CH₂Cl₂

2: 1.) trifluoroacetic anhydride, pyridine, 2.) aq. LiOH / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) THF, from 0 deg C to RT

With pyridine; lithium hydroxide; toluene-4-sulfonic acid; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1039/c39940001653