Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester
CAS No.:203063-44-9
Molecular Formula:C₃₉H₅₄O₈SSi
Molecular Weight:711.004
Hs Code.:

Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester

Synonyms:Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester

Suppliers and Price of Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester

There total 10 articles about Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 124-63-0
methanesulfonyl chloride

: 203063-43-8
(1R,2S,3S,4S)-2-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentan-1-ol

: 203063-44-9
Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 1h; Ambient temperature;

Reference yield:

: 27205-80-7
4-methoxy-3-methyl-2(5H)-furanone

: 203063-44-9
Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) LDA / 1.) THF, hexane, -20 deg C, 20 min; -78 deg C, 2 h, 2.) 1 h

2: 100 percent / H₂, NaHCO₃ / 5percent Rh/Al₂O₃ / ethyl acetate / 8 h / 5320 Torr

3: 95 percent / aq. AcOH / tetrahydrofuran / 5 h / Ambient temperature

4: PPTS / CH₂Cl₂ / 0.25 h / Ambient temperature

5: 99.4 percent / LiBEt₃H / tetrahydrofuran / 1 h / Ambient temperature

6: DMAP, Et₃N / CH₂Cl₂ / 10 h / Ambient temperature

7: NaH, TBAI / tetrahydrofuran / 12 h / Ambient temperature

8: 100 percent / aq. AcOH / 3 h / Ambient temperature

9: 97 percent / Et₃N, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; hydrogen; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium triethylborohydride; sodium hydrogencarbonate; acetic acid; triethylamine; lithium diisopropyl amide; Rh/Al₂O₃; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 78008-36-3
(R)-2,3-cyclohexylideneglyceraldehyde

: 203063-44-9
Methanesulfonic acid (1R,2R,3S,4S)-2-benzyloxy-5-(tert-butyl-diphenyl-silanyloxy)-1-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-3-methoxy-4-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) LDA / 1.) THF, hexane, -20 deg C, 20 min; -78 deg C, 2 h, 2.) 1 h

2: 100 percent / H₂, NaHCO₃ / 5percent Rh/Al₂O₃ / ethyl acetate / 8 h / 5320 Torr

3: 95 percent / aq. AcOH / tetrahydrofuran / 5 h / Ambient temperature

4: PPTS / CH₂Cl₂ / 0.25 h / Ambient temperature

5: 99.4 percent / LiBEt₃H / tetrahydrofuran / 1 h / Ambient temperature

6: DMAP, Et₃N / CH₂Cl₂ / 10 h / Ambient temperature

7: NaH, TBAI / tetrahydrofuran / 12 h / Ambient temperature

8: 100 percent / aq. AcOH / 3 h / Ambient temperature

9: 97 percent / Et₃N, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; hydrogen; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium triethylborohydride; sodium hydrogencarbonate; acetic acid; triethylamine; lithium diisopropyl amide; Rh/Al₂O₃; In tetrahydrofuran; dichloromethane; ethyl acetate;