(2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate
CAS No.:1269755-38-5
Molecular Formula:C₁₉H₂₇NO₆
Molecular Weight:365.426
Hs Code.:

Synonyms:(2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate

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Chemical Property of (2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of (2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate

There total 5 articles about (2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1146951-37-2
tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate

: 100-09-4
4-methoxybenzoic acid

: 1269755-38-5
(2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: With tributylphosphine; diamide; In benzene; at 60 ℃; for 2h;

Reference yield:

: 114676-69-6
(2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

: 1269755-38-5
(2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / dichloromethane / 18 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 70 °C

3.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

3.2: 183 h / 23 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 23 °C

5.1: tributylphosphine; diamide / benzene / 2 h / 60 °C

With 1H-imidazole; sodium tetrahydroborate; tributylphosphine; diamide; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane; benzene;

Reference yield:

: 323204-95-1
1-(tert-butyl) 2-methyl (2R,4R)-4-((tert-butyldiphenylsilyl)oxy)pyrrolidine-1,2-dicarboxylate

: 1269755-38-5
(2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 70 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

2.2: 183 h / 23 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 23 °C

4.1: tributylphosphine; diamide / benzene / 2 h / 60 °C

With sodium tetrahydroborate; tributylphosphine; diamide; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; benzene;