tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate
• CAS No.: 1146951-37-2
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231.292

Synonyms:tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate

Chemical Property of tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

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Technology Process of tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate

There total 1 articles about tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

caesium carbonate (534-17-8) + (4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline (135042-12-5,946610-68-0) + methyl iodide (74-88-4) → tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate (1146951-37-2) + (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate (114676-69-6)

Guidance literature:

In N,N-dimethyl-formamide;

Reference yield: 94.0%

tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate (1146951-37-2) + 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (123148-78-7) → tert-butyl (2R,4S)-4-[4-chloro-5-iodopyrrolo[2,3-d]pyrimidin-7-yl]-2-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 73.0%

tert-butyl (2R,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate (1146951-37-2) + p-toluenesulfonyl chloride (98-59-9) → tert-butyl (2R,4R)-2-(methoxymethyl)-4-(tosyloxy)pyrrolidine-1-carboxylate

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

upstream raw materials:

caesium carbonate

(4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline

methyl iodide

Downstream raw materials:

(2R,4S)-tert-butyl 4-(4-methoxybenzoyloxy)-2-(methoxymethyl)pyrrolidine-1-carboxylate

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