8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Base Information

• Chemical Name: 8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione
• CAS No.: 1188543-06-7
• Molecular Formula: C₃₃H₄₄F₃N₇O₄Si
• Molecular Weight: 687.838
• Mol file: 1188543-06-7.mol

Synonyms:8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Chemical Property of 8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

There total 12 articles about 8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dipropyl-8-(1H-pyrazol-4-yl)-7-(2-trimethylsilanylethoxymethyl)-3,7-dihydro-purine-2,6-dione (869788-45-4) + methanesulfonic acid 1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]ethyl ester (1188543-05-6) → 8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (1188543-06-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 75 - 80 ℃; for 16h;

DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

3-trifluoromethylaniline (98-16-8) → 8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (1188543-06-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 2.5 h / 120 - 130 °C / Sealed tube

1.2: 0.33 h / Sealed tube

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.17 h / 10 - 15 °C

2.2: 0.08 h / 10 - 15 °C

2.3: 2 h / 25 °C

3.1: tetrahydrofuran / 3 h / 0 - 20 °C

4.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C

5.1: triethylamine / dichloromethane / 0.25 h / 0 °C

5.2: 1.5 h / 10 - 15 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

5-oxo-1-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid (2357-26-8) → 8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (1188543-06-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.17 h / 10 - 15 °C

1.2: 0.08 h / 10 - 15 °C

1.3: 2 h / 25 °C

2.1: tetrahydrofuran / 3 h / 0 - 20 °C

3.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C

4.1: triethylamine / dichloromethane / 0.25 h / 0 °C

4.2: 1.5 h / 10 - 15 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2016.11.007

upstream raw materials:

5-oxo-1-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid

5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide

4-acetyl-1-(3-trifluoromethylphenyl)pyrrolidin-2-one

4-(1-hydroxyethyl)-1-(3-trifluoromethylphenyl)pyrrolidin-2-one

Downstream raw materials:

8-(1-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-3,7-dihydropurine-2,6-dione