5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide

Base Information

• Chemical Name: 5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide
• CAS No.: 1188543-02-3
• Molecular Formula: C₁₄H₁₅F₃N₂O₃
• Molecular Weight: 316.28

Synonyms:5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide

Chemical Property of 5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide

Chemical Property:

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Technology Process of 5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide

There total 3 articles about 5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5-oxo-1-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid (2357-26-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide (1188543-02-3)

Guidance literature:

5-oxo-1-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 10 - 15 ℃; for 0.166667h;

N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane; at 10 - 15 ℃; for 0.0833333h;

With triethylamine; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

2-methylenesuccinic acid (97-65-4,25119-64-6) → 5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide (1188543-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2.5 h / 120 - 130 °C / Sealed tube

1.2: 0.33 h / Sealed tube

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.17 h / 10 - 15 °C

2.2: 0.08 h / 10 - 15 °C

2.3: 2 h / 25 °C

With 1,1'-carbonyldiimidazole; In dichloromethane;

DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

3-trifluoromethylaniline (98-16-8) → 5-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid methoxy methylamide (1188543-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2.5 h / 120 - 130 °C / Sealed tube

1.2: 0.33 h / Sealed tube

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.17 h / 10 - 15 °C

2.2: 0.08 h / 10 - 15 °C

2.3: 2 h / 25 °C

With 1,1'-carbonyldiimidazole; In dichloromethane;

DOI:10.1016/j.ejmech.2016.11.007

upstream raw materials:

5-oxo-1-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid

N,O-dimethylhydroxylamine*hydrochloride

2-methylenesuccinic acid

3-trifluoromethylaniline

Downstream raw materials:

4-acetyl-1-(3-trifluoromethylphenyl)pyrrolidin-2-one

8-(1-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

4-(1-hydroxyethyl)-1-(3-trifluoromethylphenyl)pyrrolidin-2-one

methanesulfonic acid 1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]ethyl ester

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