N-Carboxy-O-benzyl-L-threonine Anhydride

Base Information

• Chemical Name: N-Carboxy-O-benzyl-L-threonine Anhydride
• CAS No.: 126094-33-5
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.24
• Mol file: 126094-33-5.mol

Synonyms:N-Carboxy-O-benzyl-L-threonine Anhydride

Chemical Property of N-Carboxy-O-benzyl-L-threonine Anhydride

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-Carboxy-O-benzyl-L-threonine Anhydride

There total 3 articles about N-Carboxy-O-benzyl-L-threonine Anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

bis(trichloromethyl) carbonate (32315-10-9) + C11H14NO3(1-)*Na(1+) → N-Carboxy-O-benzyl-L-threonine Anhydride (126094-33-5)

Guidance literature:

With 4-methyl-morpholine; In water; acetonitrile; at 20 ℃; Flow reactor;

DOI:10.1002/anie.201803549

Reference yield: 80.0%

N-Boc-O-benzyl-L-threonine (15260-10-3) → N-Carboxy-O-benzyl-L-threonine Anhydride (126094-33-5)

Guidance literature:

With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 20 ℃; for 2h; Reagent/catalyst; Temperature;

DOI:10.1021/acs.orglett.1c02224

Reference yield:

→ N-Carboxy-O-benzyl-L-threonine Anhydride (126094-33-5)

Guidance literature:

With 4-methyl-morpholine; In water; acetonitrile; at 20 ℃; for 2.77778E-05h;

In water; ethyl acetate; acetonitrile; at 20 ℃; for 0.000261111h;

upstream raw materials:

N-Boc-O-benzyl-L-threonine

bis(trichloromethyl) carbonate