ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate

Base Information

Chemical Name:ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate
CAS No.:1542756-13-7
Molecular Formula:C₂₇H₃₇NO₄
Molecular Weight:439.595
Hs Code.:

Synonyms:ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate

Suppliers and Price of ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate

There total 8 articles about ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1542755-83-8
ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-ol-4-oxy) acetate

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1542756-13-7
ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate

Guidance literature:: ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-ol-4-oxy) acetate; With potassium carbonate; In acetone; for 1h; Inert atmosphere; Sealed tube; Reflux;

(2-chloroethyl)dimethylamine hydrochloride; In acetone; Inert atmosphere; Sealed tube; Reflux;
DOI:10.1016/j.bmc.2013.10.051

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1542756-13-7
ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium; iodine / tetrahydrofuran / 6.17 h / Sealed tube; Inert atmosphere; Reflux

1.2: 20 °C / Sealed tube; Inert atmosphere

2.1: trifluoroacetic acid; triethylsilane; sodium hydrogencarbonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 20 °C

4.1: tetra-n-butylammonium tribromide / chloroform / 20 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

5.2: 80 °C / Inert atmosphere

6.1: sodium carbonate; tris-(o-tolyl)phosphine; dichlorobis(tri-O-tolylphosphine)palladium / dichloromethane; water / 0.5 h / 80 °C / Inert atmosphere; Sealed tube

6.2: 20 - 80 °C / Inert atmosphere; Sealed tube

7.1: potassium carbonate / acetone / 1 h / Inert atmosphere; Sealed tube; Reflux

7.2: Inert atmosphere; Sealed tube; Reflux

With triethylsilane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichlorobis(tri-O-tolylphosphine)palladium; tetra-n-butylammonium tribromide; iodine; potassium acetate; boron tribromide; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; magnesium; tris-(o-tolyl)phosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; acetone; 5.1: |Miyaura Borylation Reaction / 6.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2013.10.051

Reference yield:

: 92300-73-7
cyclohexyl (2-methoxyphenyl)methanol

: 1542756-13-7
ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid; triethylsilane; sodium hydrogencarbonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 20 °C

3.1: tetra-n-butylammonium tribromide / chloroform / 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

4.2: 80 °C / Inert atmosphere

5.1: sodium carbonate; tris-(o-tolyl)phosphine; dichlorobis(tri-O-tolylphosphine)palladium / dichloromethane; water / 0.5 h / 80 °C / Inert atmosphere; Sealed tube

5.2: 20 - 80 °C / Inert atmosphere; Sealed tube

6.1: potassium carbonate / acetone / 1 h / Inert atmosphere; Sealed tube; Reflux

6.2: Inert atmosphere; Sealed tube; Reflux

With triethylsilane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichlorobis(tri-O-tolylphosphine)palladium; tetra-n-butylammonium tribromide; potassium acetate; boron tribromide; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; tris-(o-tolyl)phosphine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; chloroform; water; acetone; 4.1: |Miyaura Borylation Reaction / 5.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2013.10.051