N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide

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Chemical Name:N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide
CAS No.:1415829-38-7
Molecular Formula:C₂₁H₂₀N₄O₄S
Molecular Weight:424.48
Hs Code.:

Synonyms:N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide

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Chemical Property of N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide

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Technology Process of N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide

There total 8 articles about N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.5%

: 1415830-14-6
8-chloro-3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine

: 70-55-3
toluene-4-sulfonamide

: 1415829-38-7
N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide

Guidance literature:: With potassium carbonate; tert-butyl alcohol; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; for 40h; Reflux; Inert atmosphere;

Reference yield:

: 1835-02-5
2-Bromo-1-(3,4-dimethoxyphenyl)ethanone

: 1415829-38-7
N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium azide / dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere

2.1: aluminum oxide; sodium tetrahydroborate / diethyl ether / 16 h / 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol

4.1: triethylamine / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C

5.2: 2 h / -78 - 20 °C

6.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 69 h / 20 °C / Cooling with ice

7.1: potassium carbonate; tert-butyl alcohol / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos / 40 h / Reflux; Inert atmosphere

With aluminum oxide; sodium tetrahydroborate; sodium azide; oxalyl dichloride; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; tert-butyl alcohol; palladium 10% on activated carbon; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

: 1415829-38-7
N-[3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridinium hydrobromide perbromide / chloroform; ethanol / 16 h / 50 °C

2.1: sodium azide / dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere

3.1: aluminum oxide; sodium tetrahydroborate / diethyl ether / 16 h / 20 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / methanol

5.1: triethylamine / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C

6.2: 2 h / -78 - 20 °C

7.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 69 h / 20 °C / Cooling with ice

8.1: potassium carbonate; tert-butyl alcohol / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos / 40 h / Reflux; Inert atmosphere

With aluminum oxide; sodium tetrahydroborate; sodium azide; oxalyl dichloride; hydrogen; pyridinium hydrobromide perbromide; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; tert-butyl alcohol; palladium 10% on activated carbon; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; toluene;