1-(4-fluoro-phenyl)-6-methylamino-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide

Base Information

Chemical Name:1-(4-fluoro-phenyl)-6-methylamino-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide
CAS No.:1194019-33-4
Molecular Formula:C₂₃H₂₂FN₅O₃S
Molecular Weight:467.524
Hs Code.:

Synonyms:1-(4-fluoro-phenyl)-6-methylamino-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide

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Chemical Property of 1-(4-fluoro-phenyl)-6-methylamino-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide

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Technology Process of 1-(4-fluoro-phenyl)-6-methylamino-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide

There total 9 articles about 1-(4-fluoro-phenyl)-6-methylamino-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1194019-19-6
6-bromo-1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide

: 593-51-1
methylamine hydrochloride

: 1194019-33-4
1-(4-fluoro-phenyl)-6-methylamino-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide

Guidance literature:: With sodium t-butanolate; palladium(II) acetate di-t-butylbiphenylphosphine; In 1,4-dioxane; at 90 ℃; for 2h; sealed tube; Inert atmosphere;

Reference yield:

: 864528-61-0
4-(azidomethyl)-N-methylbenzenesulfonamide

: 1194019-33-4
1-(4-fluoro-phenyl)-6-methylamino-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: cyclohexa-1,4-diene / 10 wt% Pd(OH)2 on carbon / methanol / 2 h / 65 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 5 h

3.1: sodium t-butanolate / palladium(II) acetate di-t-butylbiphenylphosphine / 1,4-dioxane / 2 h / 90 °C / sealed tube; Inert atmosphere

With cyclohexa-1,4-diene; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; sodium t-butanolate; 10 wt% Pd(OH)2 on carbon; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1194019-33-4
1-(4-fluoro-phenyl)-6-methylamino-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / trans-N,N'-dimethyl-1,2-cyclohexyldiamine / N,N-dimethyl-formamide / 20 - 120 °C / Inert atmosphere; sealed tube

2.1: water; sodium hydroxide / methanol / 1 h / Reflux

2.2: 20 °C / pH 3 - 4

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 5 h

4.1: sodium t-butanolate / palladium(II) acetate di-t-butylbiphenylphosphine / 1,4-dioxane / 2 h / 90 °C / sealed tube; Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium carbonate; triethylamine; sodium hydroxide; sodium t-butanolate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;