(2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Base Information

Chemical Name:(2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
CAS No.:117653-40-4
Molecular Formula:C₁₈H₁₉N₃O₅S
Molecular Weight:389.432
Hs Code.:

Synonyms:(2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Chemical Property of (2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Technology Process of (2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

There total 1 articles about (2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 57653-35-7
(2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 117653-40-4
(2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: In tetrahydrofuran; 1.) reflux, 3.5 h, 2.) 25 deg C, overnight;
DOI:10.1021/jo00262a026

Reference yield: 63.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 117653-40-4
(2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

: 115545-74-9,115545-75-0
Cbz-4-(2-cyanoethyl)-Pro-OMe

Guidance literature:: With tri-n-butyl-tin hydride; In tetrahydrofuran; for 10h; Heating;
DOI:10.1021/jo00262a026

Reference yield:

: 117653-40-4
(2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

: 115545-76-1
6-(benzyloxycarbonyl)-3-cyano-4-keto-6-azabicyclo<3.2.1>octane

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / n-Bu₃SnH / tetrahydrofuran / 10 h / Heating

2: 75 percent / t-BuOK / tetrahydrofuran / 0.75 h / Ambient temperature

With potassium tert-butylate; tri-n-butyl-tin hydride; In tetrahydrofuran;
DOI:10.1021/jo00262a026