1-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-3-tert-butyl-1-isobutyl-urea

Base Information

• Chemical Name: 1-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-3-tert-butyl-1-isobutyl-urea
• CAS No.: 686706-81-0
• Molecular Formula: C₁₉H₃₃N₃O₂
• Molecular Weight: 335.49

Synonyms:1-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-3-tert-butyl-1-isobutyl-urea

Chemical Property of 1-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-3-tert-butyl-1-isobutyl-urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 1-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-3-tert-butyl-1-isobutyl-urea

There total 4 articles about 1-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-3-tert-butyl-1-isobutyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(1S,2S)-1-Benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-carbamic acid tert-butyl ester (149302-10-3) → 1-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-3-tert-butyl-1-isobutyl-urea (686706-81-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/jm00054a014

Reference yield:

((S)-1-benzylallyl)carbamic acid tert-butyl ester (103127-52-2,107202-43-7) → 1-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-3-tert-butyl-1-isobutyl-urea (686706-81-0)

Guidance literature:

Multi-step reaction with 4 steps

1: m-chloroperbenzoic acid (MCPBA)

2: propan-2-ol / Heating

3: CH₂Cl₂ / Ambient temperature

4: 4 N HCl / dioxane

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; isopropyl alcohol;

DOI:10.1021/jm00054a014

Reference yield:

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane (98760-08-8) → 1-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-3-tert-butyl-1-isobutyl-urea (686706-81-0)

Guidance literature:

Multi-step reaction with 3 steps

1: propan-2-ol / Heating

2: CH₂Cl₂ / Ambient temperature

3: 4 N HCl / dioxane

With hydrogenchloride; In 1,4-dioxane; dichloromethane; isopropyl alcohol;

DOI:10.1021/jm00054a014

upstream raw materials:

[(1S,2S)-1-Benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

((S)-1-benzylallyl)carbamic acid tert-butyl ester

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol

Downstream raw materials:

{(S)-1-[(1S,2S)-1-Benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propylcarbamoyl]-2-carbamoyl-ethyl}-carbamic acid benzyl ester

(S)-N¹-[(1S,2S)-1-Benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-2-[(quinoline-2-carbonyl)-amino]-succinamide

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