(S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-isocyanopropane

Base Information

Chemical Name:(S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-isocyanopropane
CAS No.:1357622-39-9
Molecular Formula:C₁₇H₂₆BrNO₂Si
Molecular Weight:384.388
Hs Code.:

Synonyms:(S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-isocyanopropane

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Chemical Property of (S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-isocyanopropane

Chemical Property:

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Technology Process of (S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-isocyanopropane

There total 17 articles about (S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-isocyanopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357622-37-7
(S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-formylaminopropane

: 1357622-39-9
(S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-isocyanopropane

Guidance literature:: With triethylamine; trichlorophosphate; In dichloromethane; at -30 ℃; Inert atmosphere;
DOI:10.1039/c1ob06632c

Reference yield:

: 1357622-26-4
(R,E)-2-(3-bromophenoxy)methyl-5-methylhex-3-enyl acetate

: 1357622-39-9
(S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-isocyanopropane

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide / methanol / 0 °C

2.1: triethylamine / dichloromethane / -30 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

4.1: triphenylphosphine / tetrahydrofuran; water / 0 - 50 °C / Inert atmosphere

5.1: dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: ozone / methanol; dichloromethane / -78 °C / Inert atmosphere

6.2: -78 °C / Inert atmosphere

7.1: sodium tetrahydroborate / methanol; dichloromethane / -78 - -3 °C / Inert atmosphere

8.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

9.1: triethylamine; trichlorophosphate / dichloromethane / -30 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; sodium azide; ozone; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c1ob06632c

Reference yield:

: 591-20-8
3-Bromophenol

: 1357622-39-9
(S)-1-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)-3-isocyanopropane

Guidance literature:: Multi-step reaction with 10 steps

1.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 2.1 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / methanol / 0 °C

3.1: triethylamine / dichloromethane / -30 °C / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

5.1: triphenylphosphine / tetrahydrofuran; water / 0 - 50 °C / Inert atmosphere

6.1: dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: ozone / methanol; dichloromethane / -78 °C / Inert atmosphere

7.2: -78 °C / Inert atmosphere

8.1: sodium tetrahydroborate / methanol; dichloromethane / -78 - -3 °C / Inert atmosphere

9.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

10.1: triethylamine; trichlorophosphate / dichloromethane / -30 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; sodium azide; di-tert-butyl-diazodicarboxylate; ozone; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c1ob06632c