Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester
CAS No.:105823-11-8
Molecular Formula:C₂₀H₂₀N₂O₇S
Molecular Weight:432.454
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

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Chemical Property of Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

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Technology Process of Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

There total 13 articles about Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 105823-09-4
Toluene-4-sulfonic acid (2R,11aS)-7-methoxy-2-methoxymethoxy-10-methoxymethyl-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

: 105823-11-8
Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

: 105823-10-7
(2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1039/c39860000841

Reference yield:

: 83577-93-9
(2S,4R)-N-trifluoroacetyl-4-[(trifluoroacetyl)oxy]proline

: 105823-11-8
Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

Guidance literature:: Multi-step reaction with 6 steps

2: aq. NaHCO₃

3: di-isopropylethylamine

4: NH₃ / methanol

5: 69 percent / n-Bu₃N / Pd(PPh₃)4 / toluene / 24 h / 110 °C / 7600 Torr

6: 27 percent / aq. HCl / methanol

With hydrogenchloride; tributyl-amine; ammonia; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; toluene;
DOI:10.1039/c39860000841

Reference yield:

: 615-43-0
2-iodophenylamine

: 105823-11-8
Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

Guidance literature:: Multi-step reaction with 6 steps

2: 92 percent / diisopropylethylamine / CH₂Cl₂ / Ambient temperature

3: 95 percent / NaH / tetrahydrofuran / -30 °C

4: 87 percent / NH₃ / methanol

5: 69 percent / n-Bu₃N, / Pd(PPh₃)4 / toluene / 24 h / 110 °C / 7600 Torr

6: 30 percent / HCl / methanol / 20 h / 50 °C

With hydrogenchloride; tributyl-amine; ammonia; sodium hydride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)87534-7