N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)-2-bromo-4-methoxy-5-tosyloxyaniline

Base Information

Chemical Name:N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)-2-bromo-4-methoxy-5-tosyloxyaniline
CAS No.:105342-47-0
Molecular Formula:C₂₃H₂₉BrN₂O₈S
Molecular Weight:573.462
Hs Code.:

Synonyms:N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)-2-bromo-4-methoxy-5-tosyloxyaniline

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Chemical Property of N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)-2-bromo-4-methoxy-5-tosyloxyaniline

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Technology Process of N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)-2-bromo-4-methoxy-5-tosyloxyaniline

There total 10 articles about N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)-2-bromo-4-methoxy-5-tosyloxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83577-93-9
(2S,4R)-N-trifluoroacetyl-4-[(trifluoroacetyl)oxy]proline

: 105342-47-0
N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)-2-bromo-4-methoxy-5-tosyloxyaniline

Guidance literature:: Multi-step reaction with 4 steps

2: aq. NaHCO₃

3: di-isopropylethylamine

4: NH₃ / methanol

With ammonia; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In methanol;
DOI:10.1039/c39860000841

Reference yield:

: 108555-55-1
2-iodo-N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)aniline

: 105342-47-0
N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)-2-bromo-4-methoxy-5-tosyloxyaniline

Guidance literature:: With ammonia; In methanol; for 4h; Yield given;
DOI:10.1016/S0040-4020(01)87534-7

Reference yield:

: 615-43-0
2-iodophenylamine

: 105342-47-0
N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)-2-bromo-4-methoxy-5-tosyloxyaniline

Guidance literature:: Multi-step reaction with 4 steps

2: 92 percent / diisopropylethylamine / CH₂Cl₂ / Ambient temperature

3: 95 percent / NaH / tetrahydrofuran / -30 °C

4: NH₃ / methanol / 4 h

With ammonia; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)87534-7