N,N-(2RS,12RS)-2,12-dihydroxy-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis(RS)-tetrahydropapaverine

Base Information

Chemical Name:N,N-(2RS,12RS)-2,12-dihydroxy-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis(RS)-tetrahydropapaverine
CAS No.:145487-80-5
Molecular Formula:C₅₁H₆₆N₂O₁₄
Molecular Weight:931.09
Hs Code.:

Synonyms:N,N-(2RS,12RS)-2,12-dihydroxy-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis(RS)-tetrahydropapaverine

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Chemical Property of N,N-(2RS,12RS)-2,12-dihydroxy-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis(RS)-tetrahydropapaverine

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Technology Process of N,N-(2RS,12RS)-2,12-dihydroxy-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis(RS)-tetrahydropapaverine

There total 4 articles about N,N-(2RS,12RS)-2,12-dihydroxy-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis(RS)-tetrahydropapaverine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 145487-77-0
1,2,12,13-diepoxy-4,10-dioxa-3,11-dioxotridecane

: 13074-31-2
Tetrahydropapaverine

: 145487-80-5
N,N-(2RS,12RS)-2,12-dihydroxy-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis(RS)-tetrahydropapaverine

Guidance literature:: In isopropyl alcohol; at 50 ℃; for 48h;
DOI:10.1016/0223-5234(92)90180-9

Reference yield: 66.0%

: 145487-77-0
1,2,12,13-diepoxy-4,10-dioxa-3,11-dioxotridecane

: 50896-90-7
(-) N-norlaudanosine

: 145487-80-5
3-[(R)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-hydroxy-propionic acid 5-{3-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-hydroxy-propionyloxy}-pentyl ester

Guidance literature:: In isopropyl alcohol; at 50 ℃; for 48h;
DOI:10.1016/0223-5234(92)90180-9

Reference yield:

: 36840-85-4
pentamethylene 1,5-diacrylate

: 145487-80-5
N,N-(2RS,12RS)-2,12-dihydroxy-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis(RS)-tetrahydropapaverine

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / 85percent H₂O₂, trifluoroacetic anhydride, Na₂HPO₄ / CH₂Cl₂ / 3 h / 42 °C

2: 81 percent / propan-2-ol / 48 h / 50 °C

With disodium hydrogenphosphate; dihydrogen peroxide; trifluoroacetic anhydride; In dichloromethane; isopropyl alcohol;
DOI:10.1016/0223-5234(92)90180-9