50896-90-7

Basic information

• Product Name: (R)-(+)-Tetrahydropapaverine
• Synonyms: (1R)-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline;(R)-(+)-Tetrahydropapaverine;(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(3,4-dimethoxyphenyl)methyl] Isoquinoline;(1R)-1-[(3,4-diMethoxyphenyl)Methyl]-6,7-diMethoxy-1,2,3,4-tetrahydroisoquinoline;(R)-1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 50896-90-7
• Molecular Formula: C₂₀H₂₅NO₄
• Molecular Weight: 343.42
• Product Categories: Heterocyclic Compounds;Chirals
• Mol File: 50896-90-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 475.8 °C at 760 mmHg
• Flash Point: 202.7 °C
• Appearance: /
• Density: 1.120
• PKA: 8.66±0.40(Predicted)
• CAS DataBase Reference: (R)-(+)-Tetrahydropapaverine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-Tetrahydropapaverine(50896-90-7)
• EPA Substance Registry System: (R)-(+)-Tetrahydropapaverine(50896-90-7)

Safety Data

• Hazardous Substances Data: 50896-90-7(Hazardous Substances Data)

Upstream product

• 860-24-2 (R)-2-Acetyl-1-<(3,4-dimethoxyphenyl)methyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 102922-34-9 2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 6957-27-3 3,4-dihydropapaverine 
• 14301-36-1 N-[2-(3,4-dimethoxyphenyl)ethyl]formamide 
• 5884-22-0 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydrochloride 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 61348-95-6 (Z)-1-<(3,4-Dimethoxyphenyl)methylene>-2-formyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 182892-22-4 1-[(S)-6,7-Dimethoxy-1-((1R,2R,3R,4S)-1,2,3,4,5-pentahydroxy-pentyl)-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone 
• 182892-23-5 (S)-2-Acetyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-1-carbaldehyde 
• 80245-51-8 4-lithio-1,2-dimethoxybenzene 
• 321669-90-3 3-[(2'-bromo-4',5'-dimethoxyphenyl)ethyl]-2α-(3',4'-dimethoxybenzyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine 
• 321669-63-0 2α-(2'-bromo-4',5'-dimethoxyphenylmethyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine 
• 321669-67-4 N-[(2'-bromo-4',5'-dimethoxyphenyl)ethyl]-8-aminomenthol 

Downstream Products

• 64228-84-8 N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-(R)-(-)-tetrahydropapaverine 
• 64493-09-0 (RS)/meso-N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-tetrahydropapaverine 
• 145487-86-1 ethyl (2RS)-2-hydroxy-3-N-(R-tetrahydropapaverinyl)propionate 
• 145487-48-5 (-)-N,N'-4,11-dimethyl-4,11-diaza-3,12-dioxotetramethylene-1,14-diyl-bis(R)-tertahydropapaverine 
• 145487-80-5 3-[(R)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-hydroxy-propionic acid 5-{3-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-hydroxy-propionyloxy}-pentyl ester 
• 145554-12-7 N,N-(2S,13S)-2,13-dihydroxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine 
• 145554-11-6 N,N-(2R,13R)-2,13-dihydroxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine 
• 85-63-2 (R)-laudanosine 
• 123355-84-0 (R)-1-(3',4'-dimethoxyphenethyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 64229-38-5 (RS)/meso-N,N'-4,7-dioxa-3,8-dioxodecylene-1,10-diyl-bis-tetrahydropapaverine 
• 145488-06-8 N,N-(2RS,13RS)-2,13-di(ethoxycarbonyl)-3,12-dioxa-4,11-dioxotetradecylene-1,14-diyl-bis(R-tetrahydropapaverine) 
• 54417-53-7 (R)-tetrahydropapaverine hydrochloride 
• 1075726-79-2 (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-benzyloxycarbonylethyl-isoquinoline oxalate 
• 64228-81-5 cisatracurium besylate 

Relevant articles and documents

Method for synthesizing cisatracurium besilate

The invention discloses a method for synthesizing cisatracurium besilate. The method comprises the following steps of: reacting a compound shown as formula I, a compound shown as formula II and oxalicacid dihydrate to generate a compound shown as formula III; reacting the compound shown as formula III under the catalysis of Pd/C to generate a compound shown as formula IV; reacting the compound shown as formula IV with 1, 5-pentanediol to generate a compound shown as formula V; and reacting the compound shown as formula V with methyl benzenesulfonate to prepare cisatracurium besilate; whereinthe compounds shown as the formula I, the formula II, the formula III, the formula IV and the formula V are respectively represented as the specification. The synthesis method provided by the invention can significantly improve the yield and purity of cisatracurium besilate and reduce the synthesis cost of cisatracurium besilate.

Synthesis of Tetrahydroisoquinoline Alkaloids and Related Compounds through the Alkylation of Anodically Prepared α-Amino Nitriles

α-Amino nitrile 2a was conveniently prepared in two individual steps from chiral hexafluorophosphate salt isoquinolinium (-)-8b including anodic cyanation as an efficient means to activate the sp3 C1-H bond of the THIQ nucleus. The lithiation o

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A process for the resolution of racemic tetrahydropapaverine with optically active arylpropionic acids is described.