1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine

Base Information

• Chemical Name: 1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine
• CAS No.: 871976-39-5
• Molecular Formula: C₁₇H₁₅Cl₂NS
• Molecular Weight: 336.285
• Mol file: 871976-39-5.mol

Synonyms:1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine

Chemical Property of 1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine

There total 1 articles about 1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

chloroform (67-66-3,8013-54-5) + 3,4-dihydro-5-phenyl-2H-1,6-benzothiazocine (76293-51-1) → 1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine (871976-39-5)

Guidance literature:

With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; at 21 - 23 ℃; for 2h;

DOI:10.1039/b512409c

Reference yield: 73.0%

1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine (871976-39-5) → 2-(3-hydroxypropyl)-2-phenyl-2H-1,4-benzothiazin-3(4H)-one

Guidance literature:

1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine; With trifluoroacetic acid; at 20 ℃; for 2h;

With potassium hydroxide; In methanol; for 2h; Heating;

DOI:10.1039/b512409c

Reference yield: 70.0%

1,1-dichloro-1a-phenyl-1a,2,3,4-tetrahydro-1H-azirino[2,1-e][1,6]benzothiazocine (871976-39-5) → 2-(1,4-dichloro-1-phenylbutyl)-1,3-benzothiazole (871976-47-5)

Guidance literature:

With zinc(II) chloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1039/b512409c DOI:10.1134/S1070428007070214

upstream raw materials:

chloroform

3,4-dihydro-5-phenyl-2H-1,6-benzothiazocine

Downstream raw materials:

2-(1,4-dichloro-1-phenylbutyl)-1,3-benzothiazole