(2R,3S,5S)-3,5-diacetoxy-6-bis(benzyloxy)phosphoryloxy-2-methylhexanoic acid benzyl ester

Base Information

Chemical Name:(2R,3S,5S)-3,5-diacetoxy-6-bis(benzyloxy)phosphoryloxy-2-methylhexanoic acid benzyl ester
CAS No.:541513-79-5
Molecular Formula:C₃₂H₃₇O₁₀P
Molecular Weight:612.614
Hs Code.:

Synonyms:(2R,3S,5S)-3,5-diacetoxy-6-bis(benzyloxy)phosphoryloxy-2-methylhexanoic acid benzyl ester

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Chemical Property of (2R,3S,5S)-3,5-diacetoxy-6-bis(benzyloxy)phosphoryloxy-2-methylhexanoic acid benzyl ester

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Technology Process of (2R,3S,5S)-3,5-diacetoxy-6-bis(benzyloxy)phosphoryloxy-2-methylhexanoic acid benzyl ester

There total 9 articles about (2R,3S,5S)-3,5-diacetoxy-6-bis(benzyloxy)phosphoryloxy-2-methylhexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 108-24-7
acetic anhydride

: 541513-71-7
(2R,3S,5S)-6-[bis(benzyloxy)phosphoryloxy]-3,5-dihydroxy-2-methylhexanoic acid benzyl ester

: 541513-79-5
(2R,3S,5S)-3,5-diacetoxy-6-bis(benzyloxy)phosphoryloxy-2-methylhexanoic acid benzyl ester

Guidance literature:: With pyridine; dmap; at 20 ℃; for 2h;
DOI:10.1039/b210606j

Reference yield:

: 15205-57-9
tribenzyl phosphite

: 541513-79-5
(2R,3S,5S)-3,5-diacetoxy-6-bis(benzyloxy)phosphoryloxy-2-methylhexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: I₂ / CH₂Cl₂ / 0.42 h / 0 - 20 °C

2: 370 mg / pyridine / CH₂Cl₂ / 5 h / -78 °C

3: 90 percent / DMAP; pyridine / 2 h / 20 °C

With pyridine; dmap; iodine; In dichloromethane;
DOI:10.1039/b210606j

Reference yield:

: 100-39-0
benzyl bromide

: 541513-79-5
(2R,3S,5S)-3,5-diacetoxy-6-bis(benzyloxy)phosphoryloxy-2-methylhexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

2: 69 percent / CuCl₂*2H₂O / propan-2-ol / 2 h / 20 °C

3: 370 mg / pyridine / CH₂Cl₂ / 5 h / -78 °C

4: 90 percent / DMAP; pyridine / 2 h / 20 °C

With pyridine; dmap; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1039/b210606j