4-(((2S,4R)-1,2-bis((benzyloxy)carbonyl)pyrrolidin-4-yl)oxy)-4-oxobutanoic acid

Base Information

Chemical Name:4-(((2S,4R)-1,2-bis((benzyloxy)carbonyl)pyrrolidin-4-yl)oxy)-4-oxobutanoic acid
CAS No.:1352563-21-3
Molecular Formula:C₂₄H₂₅NO₈
Molecular Weight:455.464
Hs Code.:

Synonyms:4-(((2S,4R)-1,2-bis((benzyloxy)carbonyl)pyrrolidin-4-yl)oxy)-4-oxobutanoic acid

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Chemical Property of 4-(((2S,4R)-1,2-bis((benzyloxy)carbonyl)pyrrolidin-4-yl)oxy)-4-oxobutanoic acid

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Technology Process of 4-(((2S,4R)-1,2-bis((benzyloxy)carbonyl)pyrrolidin-4-yl)oxy)-4-oxobutanoic acid

There total 1 articles about 4-(((2S,4R)-1,2-bis((benzyloxy)carbonyl)pyrrolidin-4-yl)oxy)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 108-30-5
succinic acid anhydride

: 13500-53-3
N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester

: 1352563-21-3
4-(((2S,4R)-1,2-bis((benzyloxy)carbonyl)pyrrolidin-4-yl)oxy)-4-oxobutanoic acid

Guidance literature:: With pyridine; dmap; at 22 ℃; for 12h;
DOI:10.1021/ol203242r

Reference yield: 98.0%

: 1352563-21-3
4-(((2S,4R)-1,2-bis((benzyloxy)carbonyl)pyrrolidin-4-yl)oxy)-4-oxobutanoic acid

: 108-95-2,27073-41-2
phenol

: 1352563-34-8
(2S,4R)-dibenzyl 4-((4-oxo-4-phenoxybutanoyl)oxy)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform; at 0 - 22 ℃; for 12h;
DOI:10.1021/ol203242r

Reference yield:

: 1352563-21-3
4-(((2S,4R)-1,2-bis((benzyloxy)carbonyl)pyrrolidin-4-yl)oxy)-4-oxobutanoic acid

: 108-95-2,27073-41-2
phenol

: 1352563-31-5
C₁₅H₁₇NO₆

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / chloroform / 12 h / 0 - 22 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 22 °C / 760.05 Torr

With dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; chloroform;
DOI:10.1021/ol203242r