2,5-dimethyl-2-p-tolyl-2-cyclopentanone

Base Information

• Chemical Name: 2,5-dimethyl-2-p-tolyl-2-cyclopentanone
• CAS No.: 343779-02-2
• Molecular Formula: C₁₄H₁₈O
• Molecular Weight: 202.296
• Mol file: 343779-02-2.mol

Synonyms:2,5-dimethyl-2-p-tolyl-2-cyclopentanone

Chemical Property of 2,5-dimethyl-2-p-tolyl-2-cyclopentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dimethyl-2-p-tolyl-2-cyclopentanone

There total 10 articles about 2,5-dimethyl-2-p-tolyl-2-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.3%

2,5-dimethyl-2-p-tolyl-2-cyclopentenone (77183-98-3) → 2,5-dimethyl-2-p-tolyl-2-cyclopentanone (343779-02-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

bis(4-methylphenyl)iodonium bromide (6293-68-1) → 2,5-dimethyl-2-p-tolyl-2-cyclopentanone (343779-02-2)

Guidance literature:

Multi-step reaction with 7 steps

1: t-BuOK / 2-methyl-propan-2-ol / 50 h / Heating

2: 10percent H₂SO₄ / 5 h / Heating

3: 75 percent / MeONa / methanol / 8 h / Heating

4: diethyl ether / 2 h / Ambient temperature

5: 3 N aq. HCl / 1 h / Ambient temperature

6: 40 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature

7: 69.3 percent / H₂ / 5percent Pd/C / methanol

With hydrogenchloride; sulfuric acid; potassium tert-butylate; hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; tert-butyl alcohol;

Reference yield:

4,5-dioxo-cyclopentane-1,3-dicarboxylic acid diethyl ester (10088-87-6) → 2,5-dimethyl-2-p-tolyl-2-cyclopentanone (343779-02-2)

Guidance literature:

Multi-step reaction with 7 steps

1: t-BuOK / 2-methyl-propan-2-ol / 50 h / Heating

2: 10percent H₂SO₄ / 5 h / Heating

3: 75 percent / MeONa / methanol / 8 h / Heating

4: diethyl ether / 2 h / Ambient temperature

5: 3 N aq. HCl / 1 h / Ambient temperature

6: 40 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature

7: 69.3 percent / H₂ / 5percent Pd/C / methanol

With hydrogenchloride; sulfuric acid; potassium tert-butylate; hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; tert-butyl alcohol;

upstream raw materials:

2,5-dimethyl-2-p-tolyl-2-cyclopentenone

cyclopentane-1,2-dione

4,5-dioxo-cyclopentane-1,3-dicarboxylic acid diethyl ester

bis(4-methylphenyl)iodonium bromide

Downstream raw materials:

1-methyl-4-(1,2,3-trimethylcyclopent-2-en-1-yl)benzene