C₅₁H₄₁N₇O₇

Base Information

• Chemical Name: C₅₁H₄₁N₇O₇
• CAS No.: 601494-36-4
• Molecular Formula: C₅₁H₄₁N₇O₇
• Molecular Weight: 863.929
• Mol file: 601494-36-4.mol

Synonyms:C₅₁H₄₁N₇O₇

Chemical Property of C₅₁H₄₁N₇O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₁H₄₁N₇O₇

There total 10 articles about C₅₁H₄₁N₇O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-nitrophenyl)-1H-imidazole-4-carboxylic acid (601494-32-0) → C51H41N7O7 (601494-36-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 61 percent / NaH / dimethylformamide / 2 h / 80 °C

2: 95 percent / aq. NH₄Cl; Fe / ethanol / 60 °C

3: 66 percent / tetrahydrofuran / 3 h / 80 °C

4: aq. LiOH / tetrahydrofuran; methanol

5: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

6: aq. LiOH / tetrahydrofuran; methanol

7: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

8: TBAF / tetrahydrofuran

9: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

With lithium hydroxide; tetrabutyl ammonium fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; iron; sodium hydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja034563x

Reference yield:

2-(3-nitrophenyl)-4-trifluoromethyl-1H-imidazole (601494-31-9) → C51H41N7O7 (601494-36-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 79 percent / aq. NaOH / 4 h

2: 61 percent / NaH / dimethylformamide / 2 h / 80 °C

3: 95 percent / aq. NH₄Cl; Fe / ethanol / 60 °C

4: 66 percent / tetrahydrofuran / 3 h / 80 °C

5: aq. LiOH / tetrahydrofuran; methanol

6: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

7: aq. LiOH / tetrahydrofuran; methanol

8: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

9: TBAF / tetrahydrofuran

10: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

With lithium hydroxide; tetrabutyl ammonium fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; iron; sodium hydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; sodium hydroxide; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja034563x

Reference yield:

2-(3-aminophenyl)-1-(4-methoxybenzyl)-1H-imidazole-4-carboxylic acid 4-methoxybenzyl ester (601494-34-2) → C51H41N7O7 (601494-36-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 66 percent / tetrahydrofuran / 3 h / 80 °C

2: aq. LiOH / tetrahydrofuran; methanol

3: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

4: aq. LiOH / tetrahydrofuran; methanol

5: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

6: TBAF / tetrahydrofuran

7: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

With lithium hydroxide; tetrabutyl ammonium fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;

DOI:10.1021/ja034563x

upstream raw materials:

2-(3-nitrophenyl)-1H-imidazole-4-carboxylic acid

2-(3-nitrophenyl)-4-trifluoromethyl-1H-imidazole

2-(3-aminophenyl)-1-(4-methoxybenzyl)-1H-imidazole-4-carboxylic acid 4-methoxybenzyl ester

1-(4-methoxybenzyl)-2-(3-nitrophenyl)-1H-imidazole-4-carboxylic acid 4-methoxybenzyl ester