Technology Process of methyl (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate
There total 6 articles about methyl (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate which
guide to synthetic route it.
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synthetic route:
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55025-16-6
methyl (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate
- Guidance literature:
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methyl podocarpate;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 - 25 ℃;
for 0.25h;
benzyl bromide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
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55025-16-6
methyl (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate
- Guidance literature:
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Multi-step reaction with 2 steps
1: methanol; benzene
2: Cs2CO3 / dimethylformamide
With
caesium carbonate;
In
methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmcl.2005.06.100
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55025-16-6
methyl (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate
- Guidance literature:
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Multi-step reaction with 3 steps
1: 91 percent / sodium borohydride / tetrahydrofuran; H2O / 24 h
2: 81 percent / HCl / methanol / 5 h / Heating
3: 1.) borane, dimethyl sulfide, 2.) H2O2, sodium hydroxide / 1.) THF, 3.5 h, 2.) THF, water, 50 deg, 1 h
With
hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; dimethylsulfide; borane; dihydrogen peroxide;
In
tetrahydrofuran; methanol; water;
