((7S,8R)-8-Phenylsulfanylcarbonylmethyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetic acid methyl ester

Base Information

Chemical Name:((7S,8R)-8-Phenylsulfanylcarbonylmethyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetic acid methyl ester
CAS No.:122221-89-0
Molecular Formula:C₁₈H₂₂O₅S
Molecular Weight:350.436
Hs Code.:

Synonyms:((7S,8R)-8-Phenylsulfanylcarbonylmethyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetic acid methyl ester

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Chemical Property of ((7S,8R)-8-Phenylsulfanylcarbonylmethyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetic acid methyl ester

Chemical Property:

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Technology Process of ((7S,8R)-8-Phenylsulfanylcarbonylmethyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetic acid methyl ester

There total 9 articles about ((7S,8R)-8-Phenylsulfanylcarbonylmethyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 107-21-1
ethylene glycol

: 122221-88-9
((1S,2R)-4-Oxo-2-phenylsulfanylcarbonylmethyl-cyclopentyl)-acetic acid methyl ester

: 122221-89-0
((7S,8R)-8-Phenylsulfanylcarbonylmethyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetic acid methyl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In benzene;
DOI:10.1246/cl.1989.239

Reference yield:

: 25886-63-9
cis-3a,4,7,7a-tetrahydroindan-2-one

: 122221-89-0
((7S,8R)-8-Phenylsulfanylcarbonylmethyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KMnO₄, NaIO₄, Na₂CO₃; / 1.) aq. acetone; 2.) MeOH

2: 86 percent / porcine liver esterase, 0.1 M phosphate buffer / acetone / 2.5 h / Ambient temperature

3: 1.) Et-N=C=N(CH₂)3N(CH₃)2*HCl-hydroxybenzotriazole; 2.)Et₃N / 1.) THF, 0 deg C to rt; 2.) THF

4: 93 percent / pyridine-OTs / benzene

With porcine liver esterase; potassium permanganate; sodium periodate; phosphate buffer; pyridinium p-toluenesulfonate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetone; benzene;
DOI:10.1246/cl.1989.239

Reference yield:

: 25886-62-8
cis-2,2'-(cyclohex-4-ene-1,2-diyl)diacetic acid

: 122221-89-0
((7S,8R)-8-Phenylsulfanylcarbonylmethyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / HCl / methanol

2: 92 percent / NaH / dimethylsulfoxide

3: 96 percent / HMPA / H₂O / 175 °C

4: 1.) KMnO₄, NaIO₄, Na₂CO₃; / 1.) aq. acetone; 2.) MeOH

5: 86 percent / porcine liver esterase, 0.1 M phosphate buffer / acetone / 2.5 h / Ambient temperature

6: 1.) Et-N=C=N(CH₂)3N(CH₃)2*HCl-hydroxybenzotriazole; 2.)Et₃N / 1.) THF, 0 deg C to rt; 2.) THF

7: 93 percent / pyridine-OTs / benzene

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; porcine liver esterase; potassium permanganate; sodium periodate; phosphate buffer; pyridinium p-toluenesulfonate; sodium hydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; water; dimethyl sulfoxide; acetone; benzene;
DOI:10.1246/cl.1989.239