ethyl 4-chloro-2-dimethylamino-7-methyl-5-phenyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate

Base Information

• Chemical Name: ethyl 4-chloro-2-dimethylamino-7-methyl-5-phenyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate
• CAS No.: 169267-81-6
• Molecular Formula: C₁₉H₂₀ClN₃O₃
• Molecular Weight: 373.839
• Mol file: 169267-81-6.mol

Synonyms:ethyl 4-chloro-2-dimethylamino-7-methyl-5-phenyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate

Chemical Property of ethyl 4-chloro-2-dimethylamino-7-methyl-5-phenyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-chloro-2-dimethylamino-7-methyl-5-phenyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate

There total 3 articles about ethyl 4-chloro-2-dimethylamino-7-methyl-5-phenyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

dichloromethylenedimethyliminium chloride (33842-02-3,529510-96-1) + 2-amino-3-cyano-5-ethoxycarbonyl-6-methyl-4-phenyl-4H-pyran (72568-47-9) → ethyl 4-chloro-2-dimethylamino-7-methyl-5-phenyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate (169267-81-6) + ethyl 2-chlorodimethylaminomethylenamino-3-cyano-6-methyl-4-phenyl-4H-pyran-5-carboxylate

Guidance literature:

In 1,2-dichloro-ethane; for 1h; Heating;

DOI:10.1016/0040-4020(95)00258-A

Reference yield: 85.0%

ethyl 2-chlorodimethylaminomethylenamino-3-cyano-6-methyl-4-phenyl-4H-pyran-5-carboxylate → ethyl 4-chloro-2-dimethylamino-7-methyl-5-phenyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate (169267-81-6)

Guidance literature:

With hydrogenchloride; In 1,2-dichloro-ethane; Ambient temperature; stream of HCl for 3 h;

DOI:10.1016/0040-4020(95)00258-A

Reference yield:

dichloromethylenedimethyliminium chloride (33842-02-3,529510-96-1) + 2-amino-3-cyano-5-ethoxycarbonyl-6-methyl-4-phenyl-4H-pyran (72568-47-9) → ethyl 4-chloro-2-dimethylamino-7-methyl-5-phenyl-5H-pyrano<2,3-d>pyrimidin-6-carboxylate (169267-81-6)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, RT, overnight (stream of HCl for 3 h);

DOI:10.1016/0040-4020(95)00258-A

upstream raw materials:

dichloromethylenedimethyliminium chloride

2-amino-3-cyano-5-ethoxycarbonyl-6-methyl-4-phenyl-4H-pyran