72568-47-9

Usage

InChI:InChI=1/C16H16N2O3/c1-3-20-16(19)13-10(2)21-15(18)12(9-17)14(13)11-7-5-4-6-8-11/h4-8,14H,3,18H2,1-2H3

Upstream product

• 100-52-7 benzaldehyde 
• 123-54-6 acetylacetone 
• 109-77-3 malononitrile 
• 141-97-9 ethyl acetoacetate 
• 620-80-4 ethyl 2-benzylidene acetoacetate 
• 2700-22-3 Benzylidenemalononitrile 
• 15802-62-7 (Z)-ethyl 2-benzylidenacetoacetate 
• 89809-89-2 5-acetyl-2-amino-3-cyano-6-methyl-4-phenyl-4H-pyran 
• 2025-40-3 ethyl benzylidenecyanoacetate 

Downstream Products

• 4341-76-8 Ethyl 2-butynoate 
• 709-79-5 (E)-2-cyano-3-phenylacrylamide 

Relevant academic research and scientific papers

Synthesis and photoreaction of 2-amino-3-cyano-4-aryl-4H-pyrans

A series of 2-amino-3-cyano-4-aryl-4H-pyrans (1) were synthesised by reacting malononitrile, ethyl acetoacetate, and aromatic aldehydes under ultrasound irradiation. The photochemical properties, including the photostability and photoreaction of 1, were i

Novel pyrano-triazolo-pyrimidine derivatives as anti- α-amylase agents: Synthesis, molecular docking investigations and computational analysis

A novel series of pyranotriazolopyrimidine derivatives 3a-j was synthesized and characterized by 1H NMR, 13C NMR, and HRMS experimental data. The synthesized compounds were assessed for their inhibitory potential on the α-amylase enz

DFT analysis of supra-molecular assemblies of substituted 4H-pyran derivatives

This manuscript reports a theoretical characterization of two substituted pyran derivatives i.e. ethyl 6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylate 1 and ethyl 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-4H-pyran-3-carboxylate 2 using DFT calcu

One-pot, three-component synthesis of 4H-pyrans using cu(II) oxymetasilicate

4H-Pyrans are synthesized through one-pot, three-component reaction of benzaldehyde, malononitrile, and ethyl acetoacetate using Cu(II) oxymetasilicate as an efficient, reusable catalyst. The procedure offers advantages in terms of better yields, short re

First Synthesis and Structure of Ethyl 3,3,5,5-Tetracyano-2-hydroxy-2-methyl-4,6-diphenylcyclohexane-1-carboxylate

Ethyl 3,3,5,5-tetracyano-2-hydroxy-2-methyl-4,6-diphenylcyclohexane-1-carboxylate was synthesized for the first time by three-component condensation of benzaldehyde with ethyl acetoacetate and malononitrile in the presence of trichloroacetic acid. The pro

Supramolecular architectures in dihydropyridones: Synthesis, crystal structure, Hirshfeld analysis, cytotoxicity and in silico studies

In this study, a series of five non-aromatic dihydropyridones were synthesized, crystallized, and single-crystal X-ray diffraction was used to obtain their molecular geometries. The supramolecular assembly of the molecules through non-covalent interaction

Mesoporous KIT-6 supported ionic liquids as new and highly effective heterogeneous catalysts for three-component synthesis of 2-amino-3-cyano-4H-pyrans

A series of mesoporous KIT-6 supported ionic liquids were prepared and tested as effective and practical catalysts for the synthesis of 2-amino-3-cyano-4H-pyrans. The effects of type of catalysts, catalyst amount, and catalyst stability have also been inv

Choline chloride/pentaerythritol: a deep eutectic solvent for the synthesis of pyran and chromene derivatives

Abstract: A novel deep eutectic solvent system was prepared by mixing choline chloride as a hydrogen-bond acceptor with 2,2-bis(hydroxymethyl)propane-1,3-diol (pentaerythritol) as a hydrogen-bond donor. This green solvent was used for the one-pot synthesi

One-pot synthesis of 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles using sodium citrate as an organo-salt based catalyst in aqueous ethanol

Sodium citrate as a highly efficient catalyst is developed for the synthesis of functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles. This method involves a one-pot three-component reaction of aromatic aldehydes, malononitrile and 1,3

Ferric Sulfasalazine Sulfa Drug Complex Supported on Cobalt Ferrite Cellulose; Evaluation of Its Activity in MCRs

Abstract: The green and nano catalyst was simply prepared through the reaction of ferric sulfasalazine with nanomaterial CoFe2O4-cellulose as a magnetic biopolymer surface. This novel heterogeneous organometallic catalyst was charact