tert-Butyl-[(R)-1-(4-methoxy-benzyloxymethyl)-2-((S)-toluene-4-sulfinyl)-ethoxy]-diphenyl-silane

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Chemical Name:tert-Butyl-[(R)-1-(4-methoxy-benzyloxymethyl)-2-((S)-toluene-4-sulfinyl)-ethoxy]-diphenyl-silane
CAS No.:177798-90-2
Molecular Formula:C₃₄H₄₀O₄SSi
Molecular Weight:572.841
Hs Code.:

Synonyms:tert-Butyl-[(R)-1-(4-methoxy-benzyloxymethyl)-2-((S)-toluene-4-sulfinyl)-ethoxy]-diphenyl-silane

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Chemical Property of tert-Butyl-[(R)-1-(4-methoxy-benzyloxymethyl)-2-((S)-toluene-4-sulfinyl)-ethoxy]-diphenyl-silane

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Technology Process of tert-Butyl-[(R)-1-(4-methoxy-benzyloxymethyl)-2-((S)-toluene-4-sulfinyl)-ethoxy]-diphenyl-silane

There total 5 articles about tert-Butyl-[(R)-1-(4-methoxy-benzyloxymethyl)-2-((S)-toluene-4-sulfinyl)-ethoxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 177798-89-9
(R)-1-(4-Methoxy-benzyloxy)-3-((S)-toluene-4-sulfinyl)-propan-2-ol

: 177798-90-2
tert-Butyl-[(R)-1-(4-methoxy-benzyloxymethyl)-2-((S)-toluene-4-sulfinyl)-ethoxy]-diphenyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 12h;
DOI:10.1021/jo960134o

Reference yield:

: 88920-24-5
p-methoxybenzyloxy acetic acid

: 177798-90-2
tert-Butyl-[(R)-1-(4-methoxy-benzyloxymethyl)-2-((S)-toluene-4-sulfinyl)-ethoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH / 4 h / 60 °C

2: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, 30 min, 0 deg C, 2.) THF, r.t., 2 h

3: 61 percent / DIBAL / tetrahydrofuran; toluene / 0.5 h / -78 °C

4: 98 percent / imidazole / dimethylformamide / 12 h

With 1H-imidazole; n-butyllithium; diisobutylaluminium hydride; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo960134o

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 177798-90-2
tert-Butyl-[(R)-1-(4-methoxy-benzyloxymethyl)-2-((S)-toluene-4-sulfinyl)-ethoxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: NaH, Bu₄NBr / tetrahydrofuran / 1.) 25 deg C, 2.) reflux, 4 h

2: p-TsOH / 4 h / 60 °C

3: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, 30 min, 0 deg C, 2.) THF, r.t., 2 h

4: 61 percent / DIBAL / tetrahydrofuran; toluene / 0.5 h / -78 °C

5: 98 percent / imidazole / dimethylformamide / 12 h

With 1H-imidazole; n-butyllithium; tetrabutylammomium bromide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo960134o