2-CHLOROMETHYL-6,7-DIMETHOXY-3H-QUINAZOLIN-4-ONE

Base Information

• Chemical Name: 2-CHLOROMETHYL-6,7-DIMETHOXY-3H-QUINAZOLIN-4-ONE
• CAS No.: 730949-85-6
• Molecular Formula: C11H11 Cl N2 O3
• Molecular Weight: 254.673
• Hs Code.: 2933990090
• Mol file: 730949-85-6.mol

Synonyms:4(1H)-Quinazolinone,2-(chloromethyl)-6,7-dimethoxy- (9CI);2-(Chloromethyl)-6,7-dimethoxyquinazolin-4(3H)-one

Chemical Property of 2-CHLOROMETHYL-6,7-DIMETHOXY-3H-QUINAZOLIN-4-ONE

Chemical Property:

• Vapor Pressure: 6.92E-07mmHg at 25°C
• Refractive Index: 1.606
• Boiling Point: 408.6°C at 760 mmHg
• Flash Point: 200.9°C
• PSA: 64.21000
• Density: 1.41g/cm³
• LogP: 1.67910

Purity/Quality:

97% ^*data from raw suppliers

2-Chloromethyl-6,7-dimethoxy-3H-quinazolin-4-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLOROMETHYL-6,7-DIMETHOXY-3H-QUINAZOLIN-4-ONE

There total 4 articles about 2-CHLOROMETHYL-6,7-DIMETHOXY-3H-QUINAZOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 2-amino-4,5-dimethoxybenzoate (26759-46-6) + chloroacetonitrile (107-14-2) → 2-(chloromethyl)-6,7-dimethoxyquinazolin-4-(3H)-one (730949-85-6)

Guidance literature:

methyl 2-amino-4,5-dimethoxybenzoate; chloroacetonitrile; With hydrogenchloride; In 1,4-dioxane; for 2.5h; High pressure; Sonication;

In 1,4-dioxane; at 60 - 100 ℃; for 15h;

DOI:10.1002/cmdc.201300522

Reference yield: 78.0%

chloroacetonitrile (107-14-2) + 2-Amino-4,5-dimethoxybenzoic acid (5653-40-7) → 2-(chloromethyl)-6,7-dimethoxyquinazolin-4-(3H)-one (730949-85-6)

Guidance literature:

chloroacetonitrile; With sodium; In methanol; at 25 ℃; for 0.666667h; Inert atmosphere;

2-Amino-4,5-dimethoxybenzoic acid; In methanol; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.3390/molecules15129473

Reference yield: 70.0%

2-carboethoxy-4,5-dimethoxyaniline (20323-74-4) + chloroacetonitrile (107-14-2) → 2-(chloromethyl)-6,7-dimethoxyquinazolin-4-(3H)-one (730949-85-6)

Guidance literature:

With hydrogenchloride; In water; for 0.416667h; Microwave irradiation;

DOI:10.1002/jhet.30

upstream raw materials:

2-carboethoxy-4,5-dimethoxyaniline

chloroacetonitrile

2-Amino-4,5-dimethoxybenzoic acid

methyl 2-amino-4,5-dimethoxybenzoate

Downstream raw materials:

6-chloro-8-(2-hydroxybenzoyl)-2,3-dimethoxy-11H-pyrido[2,1-b]quinazolin-11-one

4-chloro-2-(chloromethyl)-6,7-dimethoxyquinazoline

2-[(4-methanesulfonylamidophenylamino)methyl]-6,7-dimethoxyquinazolin-4(3H)-one

2-[(4-methoxyphenylamino)methyl]-6,7-dimethoxyquinazolin-4(3H)-one

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