methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate

Base Information

Chemical Name:methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate
CAS No.:1370588-64-9
Molecular Formula:C₂₃H₂₈N₄O₇
Molecular Weight:472.498
Hs Code.:

Synonyms:methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate

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Chemical Property of methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate

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Technology Process of methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate

There total 2 articles about methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 87039-68-7
2-(diethylamino)-2-oxoacetyl chloride

: 1370588-46-7
2-[5-(benzoyloxy)-4-(methoxycarbonyl)-6-methoxypyrimidin-2-yl]propan-2-amine hydrochloride

: 1370588-64-9
methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 2.25h;
DOI:10.1016/j.ejmech.2012.02.015

Reference yield:

: 518048-00-5
methyl 5-(benzoyloxy)-2-(2-(benzyloxycarbonylamino)propan-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxylate

: 1370588-64-9
methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydride / 1,4-dioxane / 1 h / 40 °C

1.2: 3 h / 60 °C

2.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 3 h / 760.05 Torr

3.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 2.25 h

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; lithium hydride; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.02.015

Reference yield: 59.0%

: 1370588-64-9
methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate

: 140-75-0
para-fluorobenzylamine

: 1370588-65-0
N₁,N₁-diethyl-N₂-(2-(4-(4-fluorobenzylcarbamoyl)-5-hydroxy-6-methoxypyrimidin-2-yl)propan-2-yl)oxalamide

Guidance literature:: methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-6-methoxypyrimidine-4-carboxylate; para-fluorobenzylamine; In methanol; for 20h; Reflux; Inert atmosphere;

With sodium hydroxide;

With hydrogenchloride; In water; at 0 ℃; pH=2;
DOI:10.1016/j.ejmech.2012.02.015